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SB 202190 hydrochloride
🥰Excellent
Catalog No. T35592Cas No. 350228-36-3
Alias SB 202190 HCl
SB 202190 hydrochloride is the salt form of SB 202190.SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 with selective, cell-permeable, and antitumor activity, and also induces differentiation of human embryonic stem cells to cardiomyocytes.
SB 202190 hydrochloride
🥰Excellent
Purity: 99.99%
Catalog No. T35592Alias SB 202190 HClCas No. 350228-36-3
SB 202190 hydrochloride is the salt form of SB 202190.SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 with selective, cell-permeable, and antitumor activity, and also induces differentiation of human embryonic stem cells to cardiomyocytes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $42 | In Stock | |
| 5 mg | $60 | In Stock | |
| 10 mg | $92 | In Stock | |
| 25 mg | $148 | In Stock | |
| 50 mg | $218 | In Stock | |
| 100 mg | $325 | In Stock | |
| 200 mg | $483 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $65 | In Stock |
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Purity:99.99%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SB 202190 hydrochloride is the salt form of SB 202190.SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 with selective, cell-permeable, and antitumor activity, and also induces differentiation of human embryonic stem cells to cardiomyocytes. |
| Targets&IC50 | p38α:50 nM (IC50), p38β2:100 nM (IC50) |
| In vitro | Methods: SB 202190 hydrochloride (0-10 μM, 0-72 hours) was used to treat a subset of colorectal cancer (CRC) cell lines (RKO, CACO2, and SW480), and cell growth was measured. Results: SB 202190 hydrochloride inhibited the growth of a subset of colorectal cancer (CRC) cell lines in a dose- and time-dependent manner. [1] |
| In vivo | Methods: SB 202190 hydrochloride (dissolved in 100% DMSO and then diluted with normal saline (NS) to a final DMSO concentration of 0.1%, injected intracerebroventricularly) was administered to rats, and both the VaD model group and the sham operation group received an equal volume of 0.1% DMSO injected ICV. Eight rats in each group were examined in the Morris water maze to assess spatial learning and memory, six rats were sacrificed and brain sections were prepared for TUNEL staining and Bcl-2/caspase-3 immunohistochemistry, and six rats were sacrificed and tissue homogenates were prepared for Western blot assay of phosphorylated p38 MAPK expression. Results: Compared with the model group, the SB 202190 hydrochloride group showed a significantly shorter escape latency in the Morris water maze hidden platform test; compared with VaD model rats, the SB 202190 hydrochloride group also showed significantly reduced hippocampal neuronal apoptosis (P < 0.01) as well as higher (anti-apoptotic) Bcl-2 expression and lower (pro-apoptotic) caspase-3 expression. [2] |
| Alias | SB 202190 HCl |
| Molecular Weight | 367.8 |
| Formula | C20H15ClFN3O |
| Cas No. | 350228-36-3 |
| Smiles | Cl.FC=1C=CC(=CC1)C=2NC(=NC2C=3C=CN=CC3)C=4C=CC(O)=CC4 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (163.13 mM), Sonication and heating are recommended. DMF: 10 mg/mL (27.19 mM), Sonication and heating are recommended. Ethanol:PBS (pH 7.2) (1:10): < 1 mg/mL, insoluble, Sonication is recommended. Ethanol: 10 mg/mL (27.19 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMF/Ethanol/DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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