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Alfuzosin

Name: Alfuzosin
Brand: TargetMol
SKU: T22232
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22232Cas No. 81403-80-7

Alias SL 77499

Alfuzosin (SL 77499) is an orally available, competitive α1-adrenoceptor antagonist.Alfuzosin induces smooth muscle relaxation in the bladder neck and prostate.Alfuzosin has been used to study benign prostatic hypertrophy, lower urinary tract symptoms (LUTS), and ejaculatory dysfunction (EjD).

Alfuzosin

🥰Excellent

Purity: 99.64%

Catalog No. T22232Alias SL 77499Cas No. 81403-80-7

Pack Size	Price	Availability
10 mg	$40	In Stock
25 mg	$74	In Stock
50 mg	$123	In Stock
100 mg	$197	In Stock
500 mg	$496	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:99.64%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Alfuzosin (SL 77499) is an orally available, competitive α1-adrenoceptor antagonist.Alfuzosin induces smooth muscle relaxation in the bladder neck and prostate.Alfuzosin has been used to study benign prostatic hypertrophy, lower urinary tract symptoms (LUTS), and ejaculatory dysfunction (EjD).
In vitro	In male Wistar rats weighing 250-450 g, Alfuzosin (10 mg/kg; oral administration; single dose) increased prostatic concentrations to 4.1-8.6 times higher than plasma concentration[1].
In vivo	In male Wistar rats weighing 250-450 g, Alfuzosin (10 mg/kg; oral administration; single dose) increases prostatic concentrations to 4.1-8.6 times higher than plasma concentration[1].
Synonyms	SL 77499

Chemical Properties

Molecular Weight	389.45
Formula	C₁₉H₂₇N₅O₄
Cas No.	81403-80-7
Smiles	COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C1CCCO1
Relative Density.	1.272 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (102.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (6.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5677 mL	12.8386 mL	25.6772 mL	128.3862 mL
5 mM	0.5135 mL	2.5677 mL	5.1354 mL	25.6772 mL
10 mM	0.2568 mL	1.2839 mL	2.5677 mL	12.8386 mL
20 mM	0.1284 mL	0.6419 mL	1.2839 mL	6.4193 mL
50 mM	0.0514 mL	0.2568 mL	0.5135 mL	2.5677 mL
100 mM	0.0257 mL	0.1284 mL	0.2568 mL	1.2839 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc