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Nafcillin sodium monohydrate

Name: Nafcillin sodium monohydrate
Brand: TargetMol
SKU: T1312
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1312Cas No. 7177-50-6

Alias CL 8491

Nafcillin sodium monohydrate (CL 8491) is the sodium salt form of nafcillin, a semi-synthetic naphthalene, penicillin-related Nafcillin inhibits bacterial wall synthesis by a mechanism of action similar to penicillin. Penicillinase-resistant Nafcillin is used to treat infections caused by penicillin-resistant strains of Staphylococci.

Nafcillin sodium monohydrate

🥰Excellent

Purity: 96.62%

Catalog No. T1312Alias CL 8491Cas No. 7177-50-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$30	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:96.62%

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COA LCMS

Product Introduction

Bioactivity

Description	Nafcillin sodium monohydrate (CL 8491) is the sodium salt form of nafcillin, a semi-synthetic naphthalene, penicillin-related Nafcillin inhibits bacterial wall synthesis by a mechanism of action similar to penicillin. Penicillinase-resistant Nafcillin is used to treat infections caused by penicillin-resistant strains of Staphylococci.
Targets&IC50	β-lactamase:33 mM(Kd)
In vivo	Nafcillin sodium inactivates beta-lactamase by forming a covalent acyl-enzyme intermediate with Ser-70. At concentrations greater than 80 mM, and exposure times less than 200 seconds, Nafcillin completely inhibits the activity of beta-lactamase. Upon removal of Nafcillin, the inhibited enzyme can be fully reactivated with a rate constant of 2×10^-3/s at 25°C.
Synonyms	CL 8491

Chemical Properties

Molecular Weight	454.47
Formula	C₂₁H₂₁N₂O₅SNa·H₂O
Cas No.	7177-50-6
Smiles	O.[Na+].CCOc1ccc2ccccc2c1ON[C@H]1[C@H]2SC(C)(C)[C@@H](N2C1=O)C([O-])=O
Relative Density.	1.42 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 16 mg/mL (35.21 mM), Sonication is recommended.

H2O: 83 mg/mL (182.63 mM), Sonication is recommended.

DMSO: 84 mg/mL (184.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2004 mL	11.0018 mL	22.0037 mL	110.0183 mL
5 mM	0.4401 mL	2.2004 mL	4.4007 mL	22.0037 mL
10 mM	0.2200 mL	1.1002 mL	2.2004 mL	11.0018 mL
20 mM	0.1100 mL	0.5501 mL	1.1002 mL	5.5009 mL

H2O/DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0440 mL	0.2200 mL	0.4401 mL	2.2004 mL
100 mM	0.0220 mL	0.1100 mL	0.2200 mL	1.1002 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc