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Dimebolin

Name: Dimebolin
Brand: TargetMol
SKU: T21499
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21499Cas No. 3613-73-8

Alias Latrepirdine, Dimebone, Dimebon

Dimebolin (Latrepirdine) is a 5-HT6 antagonist.

Dimebolin

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Purity: 99.69%

Catalog No. T21499Alias Latrepirdine, Dimebone, DimebonCas No. 3613-73-8

Dimebolin (Latrepirdine) is a 5-HT6 antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$44	In Stock	In Stock
10 mg	$80	In Stock	In Stock
25 mg	$162	In Stock	In Stock
50 mg	$279	In Stock	In Stock
100 mg	$473	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.69%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Dimebolin AI Summary

Dimebolin exhibits a diverse range of bioactivities across multiple receptor systems and assays. It has notable binding affinities to several receptors, including adrenergic alpha1A (Ki = 60.26 nM), adrenergic alpha2A (Ki = 109.65 nM), dopamine D2S (Ki = 630.96 nM), 5HT2A (Ki = 61.66 nM), 5HT2C (Ki = 75.86 nM), 5HT6 (Ki = 33.88 nM), and 5HT7 (Ki = 7.943 nM). It acts as an antagonist at the 5HT6 receptor with an IC50 of 1160.0 nM, inhibiting serotonin-induced cAMP elevation. Additionally, Dimebolin exhibits antagonist activity at the human histamine H1 receptor, reducing histamine-induced calcium spikes with IC50 values of 1580.0 nM and 158.0 nM. It inhibits BuChE (IC50 = 7900.0 nM), exhibits neuroprotective effects against beta-amyloid-induced toxicity (EC50 = 25000.0 nM), blocks NMDA receptor currents (ED50 = 42.0 mg/kg), and inhibits Acetylcholinesterase (AChE) (IC50 = 45000.0 nM) as well as L-type calcium channels (IC50 = 57000.0 nM). It also demonstrates inhibitory activity on human BSEP with an IC50 value of 135900.0 nM and shows moderate antiviral potency against SARS-CoV-2. Moreover, the compound has shown potential in reducing lipid storage in Drosophila cells, reactivating p53, inhibiting Pin1, and affecting the malaria parasite proliferation. It also displays modulatory effects on various GPCRs through beta-arrestin recruitment assays, and has been identified as having both agonistic and inhibitory impacts on several serotonin receptors. Overall, Dimebolin's multi-target bioactivity profile indicates its potential utility in diverse therapeutic applications, ranging from neurological disorders to viral infections and metabolic diseases..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dimebolin (Latrepirdine) is a 5-HT6 antagonist.
Synonyms	Latrepirdine, Dimebone, Dimebon

Chemical Properties

Molecular Weight	319.44
Formula	C₂₁H₂₅N₃
Cas No.	3613-73-8
Smiles	CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
Relative Density.	1.13 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 13.75 mg/mL (43.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1305 mL	15.6524 mL	31.3048 mL	156.5239 mL
5 mM	0.6261 mL	3.1305 mL	6.2610 mL	31.3048 mL
10 mM	0.3130 mL	1.5652 mL	3.1305 mL	15.6524 mL
20 mM	0.1565 mL	0.7826 mL	1.5652 mL	7.8262 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc