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Sulfachloropyridazine

Name: Sulfachloropyridazine
Brand: TargetMol
SKU: T2184
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2184Cas No. 80-32-0

Alias Sulfachlorpyridazine

Sulfachloropyridazine (Sulfachlorpyridazine) is a sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.

Sulfachloropyridazine

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Purity: 99.66%

Catalog No. T2184Alias SulfachlorpyridazineCas No. 80-32-0

Sulfachloropyridazine (Sulfachlorpyridazine) is a sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$50	In Stock	In Stock
1 g	$72	In Stock	In Stock
5 g	$173	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.66%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Sulfachloropyridazine AI Summary

Sulfachloropyridazine demonstrates a range of bioactivities, including significant inhibition of Lamin A splicing, Human Jumonji Domain Containing 2E (JMJD2E), and the Neuropeptide S receptor, as well as activity against malarial parasite plastid, polymerases Iota, Eta, Kappa, and the USP1/UAF1 complex. It shows lower potency against the Vitamin D receptor, TGF-b, and the CRF-binding protein and CRF-R2 receptor complex, and possesses activity in blocking Ebola virus entry. The compound exhibits antimicrobial properties against various bacterial strains with minimum inhibitory concentration (MIC) values ranging from 1.0 to 32.0 µg/mL. It strongly inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells, with inhibition percentages of 95.19% and 134.92% at 10 µM, respectively. While it exhibits weak inhibitory activity against the BSEP transporter (IC50 > 1,000,000 nM), it shows antiviral activity against SARS-CoV-2, demonstrating minimal inhibitory effect in Vero E6 cells (inhibition index of 0.005744) and Caco-2 cells (0.8% inhibition at 10 µM). It also shows potential activity in HRCE cells with a hit score of 0.07178 for the SARS-CoV-2 USA-WA1/2020 strain and inhibits the 3CL-Pro protease of SARS-CoV-2 by 22.11% at 20 µM. However, it exhibits minimal inhibition of cytotoxicity in VERO-6 cells and limited activity in an HDAC6 enzymatic assay (0.35% inhibition)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Sulfachloropyridazine (Sulfachlorpyridazine) is a sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.
Synonyms	Sulfachlorpyridazine

Chemical Properties

Molecular Weight	284.72
Formula	C₁₀H₉ClN₄O₂S
Cas No.	80-32-0
Smiles	NC1=CC=C(C=C1)S(=O)(=O)NC1=CC=C(Cl)N=N1
Relative Density.	1.588 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (193.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (17.56 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5122 mL	17.5611 mL	35.1222 mL	175.6111 mL
5 mM	0.7024 mL	3.5122 mL	7.0244 mL	35.1222 mL
10 mM	0.3512 mL	1.7561 mL	3.5122 mL	17.5611 mL
20 mM	0.1756 mL	0.8781 mL	1.7561 mL	8.7806 mL
50 mM	0.0702 mL	0.3512 mL	0.7024 mL	3.5122 mL
100 mM	0.0351 mL	0.1756 mL	0.3512 mL	1.7561 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc