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Cindunistat

Catalog No. T69356 CAS 364067-22-1

Synonyms: Cindunistat free base, SD6010, SD-6010

Cindunistat (free base) is an orally available selective iNOS inhibitor for the study of arthritis.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Cindunistat, CAS 364067-22-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 258.00
5 mg	In stock	$ 642.00
10 mg	In stock	$ 913.00
25 mg	In stock	$ 1,370.00
50 mg	In stock	$ 1,850.00
100 mg	In stock	$ 2,500.00
500 mg	In stock	$ 4,900.00

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Purity: 100%

ee: 100%

Purity: 99.22%

ee: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Cindunistat (free base) is an orally available selective iNOS inhibitor for the study of arthritis.

In vivo

In 1457 patients (50 mg/day, n=485; 200 mg/day, n=486; placebo, n=486), 1048 (71.9%) completed the study. 56% had KLG3. In KLG2 patients, JSN after 48 weeks was lower with Cindunistat 50 mg/day versus placebo (p=0.032). Least-squares mean±SE JSN with Cindunistat 50 mg/day ( -0.048±0.028 mm) and 200 mg/day (-0.062±0.028 mm) were 59.9% (95% CI 6.8% to 106.9%) and 48.7% (95% CI -8.4% to 93.9%) of a placebo, improvement was not maintained at 96 weeks. No improvement was observed for KLG3 patients at either time point. Cindunistat did not improve joint pain or function but was generally well tolerated. Cindunistat (50 or 200 mg/day) did not slow the rate of JSN versus placebo. After 48 weeks, KLG2 patients showed less JSN.[1]

Synonyms	Cindunistat free base, SD6010, SD-6010
Molecular Weight	219.3
Formula	C8H17N3O2S
CAS No.	364067-22-1

Storage

store under nitrogen,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (250.8 mM)

References and Literature

1. Hellio le Graverand MP, et al. A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee. Ann Rheum Dis. 2013 Feb;72(2):187-95.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Immunology/Inflammation Compound Library

Related Products

Related compounds with same targets

FK-330 (Z)-SU4312 S-Methylisothiourea sulfate Lupeol acetate iNOS-IN-14 Pomiferin Miconazole Friedelin

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Keywords

Cindunistat 364067-22-1 Immunology/Inflammation NOS Cindunistat free base SD 6010 SD6010 SD-6010 inhibitor inhibit

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