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Cindunistat

Name: Cindunistat
Brand: TargetMol
SKU: T69356
Price: 258 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T69356Cas No. 364067-22-1

Alias SD6010, D-6010 hydrochloride maleate, Cindunistat free base

Cindunistat (free base) is an orally available selective iNOS inhibitor for the study of arthritis.

Cindunistat

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Purity: 99.92%

Catalog No. T69356Alias SD6010, D-6010 hydrochloride maleate, Cindunistat free baseCas No. 364067-22-1

Cindunistat (free base) is an orally available selective iNOS inhibitor for the study of arthritis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$258	In Stock	In Stock
5 mg	$642	In Stock	In Stock
10 mg	$913	In Stock	In Stock
25 mg	$1,370	In Stock	In Stock
50 mg	$1,850	In Stock	In Stock
100 mg	$2,500	-	In Stock
500 mg	$4,900	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.92%

ee:100%

Appearance:Solid

Color:White

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COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	Cindunistat (free base) is an orally available selective iNOS inhibitor for the study of arthritis.
In vivo	In 1457 patients (50 mg/day, n=485; 200 mg/day, n=486; placebo, n=486), 1048 (71.9%) completed the study. 56% had KLG3. In KLG2 patients, JSN after 48 weeks was lower with Cindunistat 50 mg/day versus placebo (p=0.032). Least-squares mean±SE JSN with Cindunistat 50 mg/day ( -0.048±0.028 mm) and 200 mg/day (-0.062±0.028 mm) were 59.9% (95% CI 6.8% to 106.9%) and 48.7% (95% CI -8.4% to 93.9%) of a placebo, improvement was not maintained at 96 weeks. No improvement was observed for KLG3 patients at either time point. Cindunistat did not improve joint pain or function but was generally well tolerated. Cindunistat (50 or 200 mg/day) did not slow the rate of JSN versus placebo. After 48 weeks, KLG2 patients showed less JSN.[1]
Synonyms	SD6010, D-6010 hydrochloride maleate, Cindunistat free base

Chemical Properties

Molecular Weight	219.3
Formula	C₈H₁₇N₃O₂S
Cas No.	364067-22-1
Smiles	[C@](CSCCNC(C)=N)(C(O)=O)(C)N

Storage & Solubility Information

Storage

store under nitrogen,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (250.8 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5600 mL	22.7998 mL	45.5996 mL	227.9982 mL
5 mM	0.9120 mL	4.5600 mL	9.1199 mL	45.5996 mL
10 mM	0.4560 mL	2.2800 mL	4.5600 mL	22.7998 mL
20 mM	0.2280 mL	1.1400 mL	2.2800 mL	11.3999 mL
50 mM	0.0912 mL	0.4560 mL	0.9120 mL	4.5600 mL
100 mM	0.0456 mL	0.2280 mL	0.4560 mL	2.2800 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc