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Anti-EPCR Antibody (8B109)
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Catalog No. TMAY-03486
Alias protein C receptor, endothelial
Anti-EPCR Antibody (8B109) is a Rabbit antibody targeting EPCR. Anti-EPCR Antibody (8B109) can be used in ELISA,FCM.
Anti-EPCR Antibody (8B109)
Anti-EPCR Antibody (8B109)
😃Good
Catalog No. TMAY-03486Alias protein C receptor, endothelial
Anti-EPCR Antibody (8B109) is a Rabbit antibody targeting EPCR. Anti-EPCR Antibody (8B109) can be used in ELISA,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-EPCR Antibody (8B109) is a Rabbit antibody targeting EPCR. Anti-EPCR Antibody (8B109) can be used in ELISA,FCM. |
| Alias | protein C receptor, endothelial |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 8B109 |
| Reactivity | Mouse |
| Verified Activity | Flow cytometric analysis of Mouse PROCR(CD201) expression on bEnd.3 cells. Cells were stained with purified anti-Mouse PROCR(CD201), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | ELISA,FCM |
| Recommended Dose | ELISA: 1:5000-1:10000; FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Epcr / PROCR (rM Epcr / PROCR; TMPY-02487; Q64695; Met1-Ser214). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found mainly near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depending on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC's anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other. |
| Conjucates | Unconjugated |
| Others Formats | FITC |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Mouse Epcr / PROCR Protein (TMPY-02487) |
| Antigen Species | Mouse |
| Biology Area | Serine Proteases and Regulators |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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