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Anti-BMP-1 Polyclonal Antibody
😃Good
Catalog No. TMAB-00240
Alias Procollagen C-proteinase (PCP), PCOLC, Mammalian tolloid protein (mTld), Bone morphogenetic protein 1, BMP-1, BMP1
Anti-BMP-1 Polyclonal Antibody is a Rabbit antibody targeting BMP-1. Anti-BMP-1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
Anti-BMP-1 Polyclonal Antibody
Anti-BMP-1 Polyclonal Antibody
😃Good
Catalog No. TMAB-00240Alias Procollagen C-proteinase (PCP), PCOLC, Mammalian tolloid protein (mTld), Bone morphogenetic protein 1, BMP-1, BMP1
Anti-BMP-1 Polyclonal Antibody is a Rabbit antibody targeting BMP-1. Anti-BMP-1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-BMP-1 Polyclonal Antibody is a Rabbit antibody targeting BMP-1. Anti-BMP-1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB. |
| Synonyms | Procollagen C-proteinase (PCP), PCOLC, Mammalian tolloid protein (mTld), Bone morphogenetic protein 1, BMP-1, BMP1 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Dog,Pig,Cow,Horse,Rabbit) |
| Verified Activity | 1. Tissue/cell: Rat adrenal gland; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer (0.01M, pH6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37°C for 20 min; Incubation: Anti-BMP1 Polyclonal Antibody, Unconjugated (TMAB-00240) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody and DAb staining. 2. Sample: Liver (Mouse) Lysate at 40 μg Primary: Anti-BMP1 (TMAB-00240) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 98 kDa Observed band size: 98 kDa 3. Sample: Lane 1: Mouse Placenta tissue lysates Lane 2: Mouse Cerebrum tissue lysates Lane 3: Mouse NIH/3T3 cell lysates Lane 4: Rat Placenta tissue lysates Lane 5: Human HeLa cell lysates Lane 6: Human A549 cell lysates Primary: Anti-BMP1 (TMAB-00240) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 98 kDa Observed band size: 100 kDa    |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Tissue Specificity | Ubiquitous. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Bone morphogenetic protein 1 (BMP1) was first identified in osteogenic extracts of bone. It is an extracellular zinc endopeptidase, implicated in morphogenetic processes in a broad range of species. BMP1 is a member of the astacin family of metalloproteinases. The astacin family includes BMP1, astacin, meprin A and B, tolloid-like proteins, and choriolysin. BMP1 is involved in extracellular matrix (ECM) formation, suggesting that a functional link may exist between astacin metalloproteinases, growth factors, and cell differentiation and pattern formation during development. The name PCP reflects this enzyme’s involvement in the collagen deposition of growing bone. The enzymes known as the procollagen C and N proteinases (PCP and PNP) are involved in the processing of fibrillar procollagen precursors to mature collagens, which is an essential requirement for fibril formation. PCP cleaves the C-terminus from procollagen, to allow the formation of mature, triplehelical collagen. The N-terminus is cleaved by the procollagen N-proteinase (PNP or ADAM-TS2). Defects in PNP have been linked to the skin disorder dermatosparaxis, and defects in BMP1 are thought to lead to aberrant collagen processing, and connective tissue disorders. Many forms of BMP1 have been reported, with varying truncation at the C-terminus. The long form of BMP1 is most similar to the tolloid-like proteins, which have extra EGF-like and CUB domains. |
| Immunogen | KLH conjugated synthetic peptide: human BMP1 |
| Antigen Species | Human |
| Gene Name | BMP1 |
| Gene ID | |
| Protein Name | Bone morphogenetic protein 1 |
| Uniprot ID | |
| Biology Area | Metabolism of lipids and lipoproteins,Cell differentiation,BMPs,Lipid metabolism,MMP,Collagen,Bone |
| Function | Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). |
| Molecular Weight | Theoretical: 98 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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