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IDH-305

🥰Excellent
Catalog No. T15550Cas No. 1628805-46-8

IDH-305 is an orally available, mutation-selective, and brain-penetrant IDH1 inhibitor targeting the IDH1 (R132) mutation. It is 200-fold more selective for mutant IDH1 isoforms than wild type, with IC50s of 27 nM, 28 nM, and 6.14 nM for IDH1R132H, IDH1R132C, and IDH1WT, respectively.

IDH-305

IDH-305

🥰Excellent
Purity: 99.68%
Catalog No. T15550Cas No. 1628805-46-8
IDH-305 is an orally available, mutation-selective, and brain-penetrant IDH1 inhibitor targeting the IDH1 (R132) mutation. It is 200-fold more selective for mutant IDH1 isoforms than wild type, with IC50s of 27 nM, 28 nM, and 6.14 nM for IDH1R132H, IDH1R132C, and IDH1WT, respectively.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$52In StockIn Stock
5 mg$128In StockIn Stock
10 mg$178In StockIn Stock
25 mg$369In StockIn Stock
50 mg$558In StockIn Stock
1 mL x 10 mM (in DMSO)$139In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.68%
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Product Introduction

Bioactivity
Description
IDH-305 is an orally available, mutation-selective, and brain-penetrant IDH1 inhibitor targeting the IDH1 (R132) mutation. It is 200-fold more selective for mutant IDH1 isoforms than wild type, with IC50s of 27 nM, 28 nM, and 6.14 nM for IDH1R132H, IDH1R132C, and IDH1WT, respectively.
Targets&IC50
IDH1 (WT):6.14 μM, IDH1 (R132C):28 nM, IDH1 (R132H):27 nM
In vitro
IDH-305 suppresses HCT116-IDH1R132H /- cells (IC50 of 24 nM)[1].
In vivo
P.o. administration of 30-300 mg/kg IDH-305 twice daily for 21 days suppresses 2-HG production and 2-HG-dependent tumor growth of an IDH1 mutant PDX melanoma model [1].
Chemical Properties
Molecular Weight490.45
FormulaC23H22F4N6O2
Cas No.1628805-46-8
SmilesC[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(C)c(cn2)-c2ccnc(c2)C(F)(F)F)n1
Relative Density.1.370 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (203.89 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.16 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0389 mL10.1947 mL20.3894 mL101.9472 mL
5 mM0.4078 mL2.0389 mL4.0779 mL20.3894 mL
10 mM0.2039 mL1.0195 mL2.0389 mL10.1947 mL
20 mM0.1019 mL0.5097 mL1.0195 mL5.0974 mL
50 mM0.0408 mL0.2039 mL0.4078 mL2.0389 mL
100 mM0.0204 mL0.1019 mL0.2039 mL1.0195 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Isocitrate Dehydrogenase (IDH)InhibitorinhibitIDH-305IDH305IDH1-WTIDH1WTIDH1-R132HIDH1R132HIDH1-R132CIDH1R132CIDH 305
Related Tags: buy IDH-305 | purchase IDH-305 | IDH-305 cost | order IDH-305 | IDH-305 chemical structure | IDH-305 in vivo | IDH-305 in vitro | IDH-305 formula | IDH-305 molecular weight
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