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Anti-RING2 Antibody (5I450) is a Rabbit antibody targeting RING2. Anti-RING2 Antibody (5I450) can be used in WB,IHC.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $296 | 7-10 days | |
100 μL | $498 | 7-10 days |
Description | Anti-RING2 Antibody (5I450) is a Rabbit antibody targeting RING2. Anti-RING2 Antibody (5I450) can be used in WB,IHC. |
Synonyms | Rnf2, RNF 2, RING2_HUMAN, RING1b, RING finger protein BAP-1, RING finger protein BAP1, RING finger protein BAP 1, RING finger protein 2, RING finger protein 1B, RING 2, RING 1B, Protein DinG, Polycomb M33 interacting protein Ring1B, Polycomb M33 interacting protein Ring 1B, OTTHUMP00000060668, Huntingtin-interacting protein 2-interacting protein 3, Huntingtin interacting protein 2 interacting protein 3, HIPI3, HIPI 3, HIP2-interacting protein 3, HIP2 interacting protein 3, E3 ubiquitin-protein ligase RING2, E3 ubiquitin protein ligase RING2, E3 ubiquitin protein ligase RING 2, DinG protein, DING, BAP1, BAP 1 |
Ig Type | IgG |
Reactivity | Human,Mouse,Rat |
Verified Activity | 1. Western blot analysis of RING2 on k562 cell using anti-RING2 antibody at 1/500 dilution. 2. Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-RING2 antibody. Counter stained with hematoxylin. |
Application | |
Recommended Dose | WB: 1:500-1000; IHC: 1:50-200 |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | Recombinant Antibody |
Purification | ProA affinity purified |
Appearance | Liquid |
Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
Research Background | E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable). |
Conjucates | Unconjugated |
Immunogen | Recombinant Protein |
Uniprot ID |
Molecular Weight | Theoretical: 38 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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