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Anti-P4HB Antibody-FITC (7J75)

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Catalog No. TMAY-01237F
Alias Thbp, prolyl 4-hydroxylase, β polypeptide, prolyl 4-hydroxylase, beta polypeptide, Pdia1, PDI, ERp59

Anti-P4HB Antibody-FITC (7J75) is a FITC-conjugated Rabbit antibody targeting P4HB. Anti-P4HB Antibody-FITC (7J75) can be used in FCM.

Anti-P4HB Antibody-FITC (7J75)

Anti-P4HB Antibody-FITC (7J75)

😃Good
Catalog No. TMAY-01237FAlias Thbp, prolyl 4-hydroxylase, β polypeptide, prolyl 4-hydroxylase, beta polypeptide, Pdia1, PDI, ERp59
Anti-P4HB Antibody-FITC (7J75) is a FITC-conjugated Rabbit antibody targeting P4HB. Anti-P4HB Antibody-FITC (7J75) can be used in FCM.
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25 T98 € 7-10 days
100 T200 € 7-10 days
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Product Introduction

Bioactivity
Description
Anti-P4HB Antibody-FITC (7J75) is a FITC-conjugated Rabbit antibody targeting P4HB. Anti-P4HB Antibody-FITC (7J75) can be used in FCM.
AliasThbp, prolyl 4-hydroxylase, β polypeptide, prolyl 4-hydroxylase, beta polypeptide, Pdia1, PDI, ERp59
Ig Type
Monoclonal Rabbit IgG
Clone
7J75
Reactivity
Human
Verified Activity
Human P4HB (PDI) expression in HeLa cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and stained with FITC-conjugated Rabbit anti-P4HB (PDI). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Application
FCM
Recommended Dose
10 μl/Test, 0.1 mg/ml
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human P4HB (rh P4HB; TMPY-01012; NP_000909.2; Met 1-Lys 505) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
PurificationProtein A
AppearanceLiquid
FormulationPBS solution containing 0.5% BSA and 0.1% sodium azide
Research BackgroundProtein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein that belongs to the protein disulfide isomerase family. P4HB is highly abundant. In some cell types, it seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources. P4HB localizes near CD4-enriched regions on lymphoid cell surfaces. It is identified by mass spectrometry in melanosome fractions from stage I to stage IV. P4HB reduces and may activate fusogenic properties of HIV-1 gp12 surface protein, thereby enabling HIV-1 entry into the cell. P4HB catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, it seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. P4HB may therefore cause structural modifications of exofacial proteins. Inside the cell, it seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, P4HB functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, it facilitates aggregation (anti-chaperone activity). P4HB may be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. It also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.
Related Conjugates and Formulations
Conjucates
FITC
Others Formats
Unconjugated
Antibody Types Available
2
Antigen Details
Immunogen
Recombinant Human P4HB protein (TMPY-01012)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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