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Anti-CD146/MCAM Antibody-FITC (7O187)
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Catalog No. TMAY-03462F
Alias MUC18, melanoma cell adhesion molecule, CD146
Anti-CD146/MCAM Antibody-FITC (7O187) is a FITC-conjugated Rabbit antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody-FITC (7O187) can be used in FCM.
Anti-CD146/MCAM Antibody-FITC (7O187)
Anti-CD146/MCAM Antibody-FITC (7O187)
😃Good
Catalog No. TMAY-03462FAlias MUC18, melanoma cell adhesion molecule, CD146
Anti-CD146/MCAM Antibody-FITC (7O187) is a FITC-conjugated Rabbit antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody-FITC (7O187) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 T | $105 | 7-10 days | |
| 100 T | $258 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD146/MCAM Antibody-FITC (7O187) is a FITC-conjugated Rabbit antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody-FITC (7O187) can be used in FCM. |
| Alias | MUC18, melanoma cell adhesion molecule, CD146 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 7O187 |
| Reactivity | Mouse |
| Verified Activity | Flow cytometric analysis of Mouse MCAM(CD146) expression on BABL/c splenocytes. Cells were stained with FITC-conjugated anti-Mouse MCAM(CD146) and PE conjugated anti-mouse CD49b (BD Pharmingen™ Cat. No. 558759). The dot plots were derived from events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD146/MCAM (rM CD146/MCAM; TMPY-02502; Q8R2Y2-1; Met1-Val563) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region, and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumors, and thus has been suggested to play an important role in tumor progression and the development of metastasis in certain human carcinomas. |
| Conjucates | FITC |
| Others Formats | Unconjugated/APC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Mouse CD146/MCAM Protein (TMPY-02502) |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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