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Risperidone
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Catalog No. T0351Cas No. 106266-06-2
Alias Risperidal, R 64 766
Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
Risperidone
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Purity: 99.73%
Catalog No. T0351Alias Risperidal, R 64 766Cas No. 106266-06-2
Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $43 | In Stock | In Stock | |
| 25 mg | $54 | In Stock | In Stock | |
| 50 mg | $85 | In Stock | In Stock | |
| 100 mg | $130 | In Stock | In Stock | |
| 200 mg | $213 | In Stock | In Stock | |
| 500 mg | $358 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.73%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent. |
| Targets&IC50 | D3 receptor:3.6 nM(Ki), 5-HT2A:0.17 nM(Ki), D2L receptor:4.16 nM(Ki), D2 receptor:3.57 nM(Ki), α2C-adrenoceptor:1.3 nM(Ki) |
| In vitro | In rats, Risperidone (0.5 mg/kg) results in diminished weight gain and enhanced UCP1 gene expression in BAT, along with elevated serum prolactin levels. At a dose of (0.05 mg/kg), Risperidone increases food intake and leptin gene expression in white adipose tissue without affecting the rate of weight gain. |
| In vivo | In activated microglia, Risperidone significantly inhibits the production of NO and pro-inflammatory cytokines. In Caco-2 cells, Risperidone (1-50 mM) notably enhances the intracellular accumulation of Rh123 by inhibiting the activity of P-gp, with an IC50 value of 5.87 mM. |
| Synonyms | Risperidal, R 64 766 |
| Molecular Weight | 410.48 |
| Formula | C23H27FN4O2 |
| Cas No. | 106266-06-2 |
| Smiles | CC1=C(CCN2CCC(CC2)C2=NOC3=CC(F)=CC=C23)C(=O)N2CCCCC2=N1 |
| Relative Density. | 1.38 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.11 mg/mL (10.01 mM), Sonication is recommended. Ethanol: 4.11 mg/mL (10.01 mM), Sonication is recommended. | ||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.44 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO/Ethanol
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
α2C-adrenergic receptorSerotonin ReceptorRisperidoneP-gp (P-glycoprotein)P-gpPgpP-glycoproteinMultidrug resistance protein 1MDR1InhibitorinhibitDopamineReceptorDopamine ReceptorDopamineD3D2LD2Cluster of differentiation 243CD243AdrenergicReceptorAdrenergic ReceptorABCB15-hydroxytryptamine Receptor5HTReceptor5-HT2A5-HT Receptor5HT Receptor
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