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Risperidone
🥰Excellent
Catalog No. T0351Cas No. 106266-06-2
Alias Risperidal, R 64 766
Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
Risperidone
🥰Excellent
Purity: 99.73%
Catalog No. T0351Alias Risperidal, R 64 766Cas No. 106266-06-2
Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $43 | In Stock | |
| 25 mg | $54 | In Stock | |
| 50 mg | $85 | In Stock | |
| 100 mg | $130 | In Stock | |
| 200 mg | $213 | In Stock | |
| 500 mg | $358 | In Stock |
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Purity:99.73%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent. |
| Targets&IC50 | D3 receptor:3.6 nM(Ki), 5-HT2A:0.17 nM(Ki), α2C-adrenoceptor:1.3 nM(Ki), D2 receptor:3.57 nM(Ki), D2L receptor:4.16 nM(Ki) |
| In vitro | In rats, Risperidone (0.5 mg/kg) results in diminished weight gain and enhanced UCP1 gene expression in BAT, along with elevated serum prolactin levels. At a dose of (0.05 mg/kg), Risperidone increases food intake and leptin gene expression in white adipose tissue without affecting the rate of weight gain. |
| In vivo | In activated microglia, Risperidone significantly inhibits the production of NO and pro-inflammatory cytokines. In Caco-2 cells, Risperidone (1-50 mM) notably enhances the intracellular accumulation of Rh123 by inhibiting the activity of P-gp, with an IC50 value of 5.87 mM. |
| Synonyms | Risperidal, R 64 766 |
| Molecular Weight | 410.48 |
| Formula | C23H27FN4O2 |
| Cas No. | 106266-06-2 |
| Smiles | CC1=C(CCN2CCC(CC2)C2=NOC3=CC(F)=CC=C23)C(=O)N2CCCCC2=N1 |
| Relative Density. | 1.38 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 4.1 mg/mL (9.99 mM), Sonication is recommended. Ethanol: 4.1 mg/mL (9.99 mM), Sonication is recommended. | |||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.44 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO/Ethanol
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
α2C-adrenergic receptorSerotonin ReceptorRisperidoneP-gp (P-glycoprotein)P-gpPgpP-glycoproteinMultidrug resistance protein 1MDR1InhibitorinhibitDopamineReceptorDopamine ReceptorDopamineD3D2LD2Cluster of differentiation 243CD243AdrenergicReceptorAdrenergic ReceptorABCB15-hydroxytryptamine Receptor5HTReceptor5-HT2A5-HT Receptor5HT Receptor
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