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Vandetanib hydrochloride

Catalog No. T21641   CAS 524722-52-9

Vandetanib hydrochloride (D6474 hydrochloride) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity with IC 50 of 40 nM. Vandetanib hydrochloride also has some additional activity versus the tyrosine kinase activity of VEGFR3/FLT4 ( IC 50 =110 nM) and EGFR/HER1 ( IC 50 =500 nM) [1].

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Vandetanib hydrochloride Chemical Structure
Vandetanib hydrochloride, CAS 524722-52-9
Pack Size Availability Price/USD Quantity
25 mg 6-8 weeks $ 1,520.00
50 mg 6-8 weeks $ 1,980.00
100 mg 6-8 weeks $ 2,500.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Vandetanib hydrochloride (D6474 hydrochloride) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity with IC 50 of 40 nM. Vandetanib hydrochloride also has some additional activity versus the tyrosine kinase activity of VEGFR3/FLT4 ( IC 50 =110 nM) and EGFR/HER1 ( IC 50 =500 nM) [1].
In vitro Vandetanib effectively inhibits VEGFR3 and EGFR, showing IC50 values of 110 nM and 500 nM, respectively. It exhibits markedly less sensitivity towards PDGFRβ, Flt1, Tie-2, and FGFR1, with IC50 values ranging from 1.1 to 3.6 μM and demonstrates negligible activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt, and IGF-1R, all with IC50 values exceeding 10 μM. Notably, Vandetanib reduces the proliferation of HUVECs stimulated by VEGF, EGF, and bFGF, registering IC50 values of 60 nM, 170 nM, and 800 nM, respectively, while sparing unstimulated basal endothelial cell growth. Additionally, it varies in inhibiting tumor cell growth, with IC50 values ranging from 2.7 μM in A549 cells to 13.5 μM in Calu-6 cells. In contrast, Odanacatib demonstrates only weak inhibition of antigen presentation in a mouse B cell line (IC50 = 1.5±0.4 μM) and minimal effect on the processing of the MHC II invariant chain protein IiP10 in mouse splenocytes, when compared to the more potent Cat S inhibitor LHVS. Vandetanib also suppresses the phosphorylation of VEGFR-2 in HUVECs and EGFR in hepatoma cells, further inhibiting cell proliferation.
In vivo Vandetanib (15 mg/kg, orally) demonstrates a markedly stronger anti-tumor effect compared to gefitinib in the H1650 xenograft model, with an IC50 value of 3.5±1.2 μM for tumor growth inhibition [3]. In mice with tumors, vandetanib administration at doses of 50 or 75 mg/kg leads to the suppression of VEGFR-2 and EGFR phosphorylation in tumor tissues. This results in a significant reduction of tumor vessel density, an increase in tumor cell apoptosis, inhibition of tumor growth, enhanced survival, decreased intrahepatic metastases, and elevated levels of VEGF, TGF-α, and EGF within the tumor tissues [4].
Molecular Weight 511.81
Formula C22H25BrClFN4O2
CAS No. 524722-52-9

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Vandetanib hydrochloride 524722-52-9 Vandetanib Hydrochloride inhibitor inhibit

 

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