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CAY10526 (Synonyms: CAY-10526, CAY 10526, BTH)

Name: CAY10526
Brand: TargetMol
SKU: T23861
Price: 54 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T23861 Copy Product Info

Purity: 98.75%

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CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway.

CAY10526

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Catalog No. T23861

Synonyms CAY-10526, CAY 10526, BTH

CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway.

Cas No. 938069-71-7

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Pack Size	Price	USA Stock	Global Stock
1 mg	$54	-	In Stock
5 mg	$139	-	In Stock
10 mg	$222	-	In Stock
25 mg	$446	-	In Stock
1 mL x 10 mM (in DMSO)	$153	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.75%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway.
Targets&IC50	mPGES-1:1.8 μM
In vitro	CAY10526 dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC50 value of 1.8 μM without any effect on COX-2 expression[1].
Synonyms	CAY-10526, CAY 10526, BTH

Chemical Properties

Molecular Weight	311.15
Formula	C₁₂H₇BrO₃S
Cas No.	938069-71-7
Smiles	OC1OC(=O)C(Br)=C1c1cc2ccccc2s1
Relative Density.	1.889 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16 mg/mL (51.42 mM), Sonication is recommended.

DMF: 16 mg/mL (51.42 mM), Sonication is recommended.

Ethanol: 1 mg/mL (3.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 1.5 mg/mL (4.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO/DMF

	1mg	5mg	10mg	50mg
1 mM	3.2139 mL	16.0694 mL	32.1388 mL	160.6942 mL

DMSO/DMF

	1mg	5mg	10mg	50mg
5 mM	0.6428 mL	3.2139 mL	6.4278 mL	32.1388 mL
10 mM	0.3214 mL	1.6069 mL	3.2139 mL	16.0694 mL
20 mM	0.1607 mL	0.8035 mL	1.6069 mL	8.0347 mL
50 mM	0.0643 mL	0.3214 mL	0.6428 mL	3.2139 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc