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1-Linoleoyl Glycerol

Name: 1-Linoleoyl Glycerol
Brand: TargetMol
SKU: T10017
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10017Cas No. 2277-28-3

Alias Monolinolein, Glyceryl monolinoleate, Glycerol 1-monolinolate, 1-Linoleoyl-rac-glycerol

1-Linoleoyl Glycerol (Monolinolein) is fatty acid glycerol that has been isolated from Saururus Chinensis roots. The (R)-1-Linoleoyl Glycerol and (S)-1-Linoleoyl Glycerol exhibit Lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitory activities with IC50 values of 45.0 and 52.0 μM, respectively.

1-Linoleoyl Glycerol

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Purity: 99.15%

Catalog No. T10017Alias Monolinolein, Glyceryl monolinoleate, Glycerol 1-monolinolate, 1-Linoleoyl-rac-glycerolCas No. 2277-28-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$55	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.15%

Appearance:Liquid

Color:Yellow

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COA HPLC HNMR

Product Introduction

1-Linoleoyl Glycerol AI Summary

1-Linoleoyl Glycerol shows cytotoxicity against human LNCAP cells after 48 hours as determined by the MTT assay. The IC50 value for this compound is greater than 100,000 nM, indicating a relatively low level of cytotoxic activity against LNCAP cells in this specific assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1-Linoleoyl Glycerol (Monolinolein) is fatty acid glycerol that has been isolated from Saururus Chinensis roots. The (R)-1-Linoleoyl Glycerol and (S)-1-Linoleoyl Glycerol exhibit Lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitory activities with IC50 values of 45.0 and 52.0 μM, respectively.
Targets&IC50	Lp-PLA2:52.0 μM((S)-1-Linoleoyl Glycerol), Lp-PLA2:45.0 μM((R)-1-Linoleoyl Glycerol)
Synonyms	Monolinolein, Glyceryl monolinoleate, Glycerol 1-monolinolate, 1-Linoleoyl-rac-glycerol

Chemical Properties

Molecular Weight	354.52
Formula	C₂₁H₃₈O₄
Cas No.	2277-28-3
Smiles	CCCCCC=CCC=CCCCCCCCC(=O)OCC(O)CO
Relative Density.	0.981 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 88 mg/mL (248.22 mM), Sonication is recommended.

DMSO: 88 mg/mL (248.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8207 mL	14.1036 mL	28.2072 mL	141.0358 mL
5 mM	0.5641 mL	2.8207 mL	5.6414 mL	28.2072 mL
10 mM	0.2821 mL	1.4104 mL	2.8207 mL	14.1036 mL
20 mM	0.1410 mL	0.7052 mL	1.4104 mL	7.0518 mL
50 mM	0.0564 mL	0.2821 mL	0.5641 mL	2.8207 mL
100 mM	0.0282 mL	0.1410 mL	0.2821 mL	1.4104 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc