Alunacedase alfa (APN-01) is a soluble angiotensin-converting enzyme 2 (hrsACE2) with antiviral activity that reduces the competitive entry of SARS-CoV-2 into cell membranes bound to ACE2. alunacedase alfa mimics ACE2 in vivo and can be used to study novel coronavirus infections, pulmonary hypertension and acute lung injury. Alunacedase alfa mimics ACE2 in vivo and can be used to study novel coronavirus infections, pulmonary hypertension and acute lung injury.

Recifercept (TA-46) is a recombinant human soluble fibroblast growth factor receptor 3, a decoy protein that competes for the ligand of mutant FGFR3.Recifercept is used in the study of chondrodysplasia because it restores normal bone growth by preventing negative inhibitory signaling of mutant FGFR3 in patients with pediatric chondrodysplasia.Recifercept is a recombinant human recombinant fibroblast growth factor receptor 3 that competes for the ligand of mutant FGFR3.

Ibritumomab tiuxetan (IDEC-129) is an antibody targeting CD20, conjugated to a radioactive isotope via a chelating agent Tiuxetan, and can be used in radioimmunotherapy.

Inpegsomatropin is a long-acting recombinant human growth hormone that has been pegylated.

Aritinercept is a fusion protein/cytokine derivative related to TNFSF13B/BAFF/CD257 and can be used for immunology research.

C1 Esterase Inhibitor (Human) is a glycoprotein derived from human plasma and acts as a serine protease inhibitor. It inactivates enzymes like C1r, C1s, and mannose-binding lectin-associated serine proteases (MASP) through covalent binding. This compound possesses anti-inflammatory properties and is utilized to prevent angioedema attacks associated with hereditary angioedema.

Adargiminase is an enzyme/recombinant protein related to arginine and can be used for oncology research.

Peginterferon alfacon-2 is a human antibody targeting IFNAR1/2 [1].

Zolimomab aritox (H65-RTA) is a complex immunocoupling agent that connects a monoclonal antibody (H65) targeting the pan-T-cell antigen CD5 with the ribosomal inhibitory protein ricin (RTA). This compound demonstrates anticancer properties and is applicable in research on cutaneous T-cell lymphoma [1].

Palsucibep pegol is an engineered protein that specifically binds to human lipocalin-2. It also targets hepcidin [1].

Alacizumab pegol (CDP-791), a pegylated antibody fragment targeting KDR, is utilized in cancer research [1].

Tolododekin alfa, consists of full-length human IL-12 stably conjugated to aluminum hydroxide. It can be used for research on IL-12-mediated immune activation, tumor immunology, and the immune microenvironment.

Peginterferon alfa-2a is a recombinant protein/biologic targeting IFNα-2a and can be used for infectious disease research.

Efadirelaxin alfa is a recombinant protein/biologic targeting RXFP1 and can be used for metabolism research.

Zinihyaluronidase alfa is an enzyme/recombinant protein related to hyaluronan and can be used for life science research.

Epoetin beta (rhEPO), a recombinant erythropoietin, is crucial for sustaining erythropoiesis and is utilized in anemia research [1].

Loncipoetin alfa is a recombinant protein/biologic targeting erythropoietin receptor and can be used for hematology research.

Zafinofusp alfa is a fusion protein associated with human N-sulphoglucosamine sulphohydrolase (SGSH, sulfamidase, EC 3.10.1.1). SGSH is a lysosomal enzyme involved in glycosaminoglycan degradation, so Zafinofusp alfa can be used for research on lysosomal function, glycosaminoglycan metabolism, and metabolic disease-related studies.

Cepeginterferon alfa-2b, a pegylated interferon, features a polyethylene glycol (PEG) base with a molecular weight of 20 kDa. This compound is utilized in the research of numerous diseases, including hepatitis C virus (HCV), polycythemia vera (PV), and essential thrombocythemia (ET) [1] [2].

Aflibercept is a recombinant fusion protein antibody composed of the Ig domains of VEGFR1 and VEGFR2 and the Fc domain of human IgG1. Aflibercept inhibits VEGF signaling and is a commonly used tool in biological research for suppressing pathological angiogenesis.

Abicipar pegol (AGN-150998, MP0112), an anti-VEGF DARPin molecule, is a novel class of small ankyrin repeat domain-containing proteins designed for high specificity and affinity targeting. This compound effectively inhibits angiogenesis and vascular permeability, and has been applied in ocular inflammation-related disease studies through intravitreal injections, significantly reducing mean retinal thickness and leakage area [1] [2].

Eftezirleukin alfa is a fusion protein composed of a human IgG4 Fc fragment and an interleukin-2 derivative. It is an IL-2 pathway-related immunomodulatory molecule and can be used for research on IL-2 signaling, immune regulation, and tumor immunology. Its structural annotation includes a human IgG4 Fc fragment fused to a human IL-2 fragment variant.