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Anti-TPH2 Polyclonal Antibody
(Synonyms: Tryptophan 5-monooxygenase 2, Tryptophan 5-hydroxylase 2, TPH2, NTPH, Neuronal tryptophan hydroxylase) Copy Product Info
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Synonyms: Tryptophan 5-monooxygenase 2, Tryptophan 5-hydroxylase 2, TPH2, NTPH, Neuronal tryptophan hydroxylase
Catalog No. TMAB-01879 Copy Product Info
🥰Excellent
Anti-TPH2 Polyclonal Antibody is a Rabbit antibody targeting TPH2. Anti-TPH2 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
Anti-TPH2 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-TPH2 Polyclonal Antibody is a Rabbit antibody targeting TPH2. Anti-TPH2 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB. |
| Synonyms | Tryptophan 5-monooxygenase 2, Tryptophan 5-hydroxylase 2, TPH2, NTPH, Neuronal tryptophan hydroxylase |
| Ig Type | IgG |
| Reactivity | Human,Rat (predicted:Mouse,Cow,Horse) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Tissue Specificity | Brain specific. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH), tryptophan hydroxylase (TPH) and tryptophan hydroxylase 2 (TPH2) comprise a small family of monooxygenases that catalyze the rate-limiting step in the catabolism of aromatic L-amino acids and utilize tetrahydropterine as a cofactor. TPH2 is highly expressed in the central nervous system (CNS), mainly in the brain. TPH2 catalyzes the first step in the biosynthesis of serotonin in the CNS and melatonin in the pineal gland, and may be involved in the pathology of several neuropsychiatric disorders. Glucocorticoid-mediated reduction of TPH2 is associated with the etiology of mood disorders, specifically psychotic major depression, and TPH2 may be related to dysregulation of serotonin neurotransmission in the brain which commonly leads to suicidal behavior. |
| Immunogen | KLH conjugated synthetic peptide: human TPH2 |
| Antigen Species | Human |
| Gene Name | TPH2 |
| Gene ID | |
| Protein Name | Tryptophan 5-hydroxylase 2 |
| Uniprot ID | |
| Biology Area | Serotonin / 5HT |
| Molecular Weight | Theoretical: 54 kDa. Actual: 60 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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