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SK1-I hydrochloride
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Catalog No. T60798Cas No. 2366222-05-9
Alias BML-258 hydrochloride, BML258 hydrochloride
SK1-I hydrochloride is the salt form of SK1-I(BML-258). SK1-I is a selective and competitive sphingosine kinase 1 (SphK1) inhibitor and sphingosine analog that is inactive against SphK2 and a variety of other protein kinases, and possesses anti-leukemic potential to inhibit tumor cell growth and promote apoptosis.
SK1-I hydrochloride
😃Good
Purity: 99.80%
Catalog No. T60798Alias BML-258 hydrochloride, BML258 hydrochlorideCas No. 2366222-05-9
SK1-I hydrochloride is the salt form of SK1-I(BML-258). SK1-I is a selective and competitive sphingosine kinase 1 (SphK1) inhibitor and sphingosine analog that is inactive against SphK2 and a variety of other protein kinases, and possesses anti-leukemic potential to inhibit tumor cell growth and promote apoptosis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $136 | In Stock | In Stock | |
| 5 mg | $332 | In Stock | In Stock | |
| 10 mg | $572 | In Stock | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,410 | - | In Stock | |
| 100 mg | $1,990 | - | In Stock | |
| 200 mg | $2,680 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.80%
Appearance:Viscous
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SK1-I hydrochloride is the salt form of SK1-I(BML-258). SK1-I is a selective and competitive sphingosine kinase 1 (SphK1) inhibitor and sphingosine analog that is inactive against SphK2 and a variety of other protein kinases, and possesses anti-leukemic potential to inhibit tumor cell growth and promote apoptosis. |
| In vitro | The effect of SK1-I hydrochloride on cancer cell growth, survival, and apoptosis is closely related to the TP53 status. Treatment of HCT116 cells with a defective TP53 mutation and normal HCT116 cells with SK1-I hydrochloride (0-10μM) for 24 hours revealed that the growth and survival rate of normal HCT116 cells decreased significantly. In protein blot analysis, after treating both cell types with SK1-I hydrochloride (0-20μM) for 12 hours, it was found that CASP3 cleavage was increased in normal HCT116 cells, making them more prone to apoptosis [1]. |
| In vivo | In the C57BL/6 male mouse model, pretreatment with SK1-I hydrochloride (intraperitoneal injection, 75mg/kg, a single dose administered 24 hours before baseline mean arterial pressure measurement) showed a significant hypotensive effect, significantly reducing the baseline mean arterial pressure (MAP) [2]. |
| Synonyms | BML-258 hydrochloride, BML258 hydrochloride |
| Molecular Weight | 313.86 |
| Formula | C17H28ClNO2 |
| Cas No. | 2366222-05-9 |
| Smiles | C(=C/[C@@H]([C@@H](CO)NC)O)\C1=CC=C(CCCCC)C=C1.Cl |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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