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Tetrac

Catalog No. T36715 CAS 67-30-1

Synonyms: Tetraiodothyroacetic acid, 3,3',5,5'-Tetraiodothyroacetic acid

Tetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking EGFR-mediated cell signaling in colorectal cancer cells.Tetrac blocks the effects of T4 and 3,5,3'-triiodo-L-thyronine (T3) on the cell-surface thyroxine integrin αvβ3 receptors.Tetra has anti-angiogenic, anti-tumor activity and pro-apoptotic activity.

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Tetrac, CAS 67-30-1

Pack Size	Availability	Price/USD
10 mg	In stock	$ 39.00
25 mg	In stock	$ 79.00
50 mg	In stock	$ 118.00
100 mg	In stock	$ 173.00
500 mg	In stock	$ 438.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 99.04%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking EGFR-mediated cell signaling in colorectal cancer cells.Tetrac blocks the effects of T4 and 3,5,3'-triiodo-L-thyronine (T3) on the cell-surface thyroxine integrin αvβ3 receptors.Tetra has anti-angiogenic, anti-tumor activity and pro-apoptotic activity.
In vitro	Tetrac (0.01-1 μM; 2-6 d) induces anti-proliferation in HT-29 and HCT116 cells with different K-RAS status[3].Tetrac (0.1 μM; 30 min) inhibits activation of ERK1/2 in HT-29 and HCT116 cells[3].Tetrac (0.1 μM; 24 h) inhibits expression of CCND1 and c-Myc, but promotes expression of CASP2 and THBS1[3]. Cell Proliferation Assay[3] Cell Line: HT-29 and HCT116 cells
In vivo	Tetrac (35 μg/day; p.o.; for 40 days; Wild-type male Balb/C mice inoculated with 102B16F10 or B16LS9 cells) delayed the onset of ocular melanoma and reduced the S-100 and integrin staining levels. Tetrac can inhibit tumor inoculation, growth, and integrin expression in mice.[4]

Synonyms	Tetraiodothyroacetic acid, 3,3',5,5'-Tetraiodothyroacetic acid
Molecular Weight	747.83
Formula	C14H8I4O4
CAS No.	67-30-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 74.78 mg/mL (100 mM)

References and Literature

1. Schmohl KA, et al. Tetrac as an anti-angiogenic agent in cancer. Endocr Relat Cancer. 2019;26(6):R287-R304. 2. Davis PJ, et, al. Nongenomic Actions of Thyroid Hormone: the Integrin Component. Physiol Rev. 2020 Jun 25. 3. Chin YT, et, al. Tetrac and NDAT Induce Anti-proliferation via Integrin αvβ3 in Colorectal Cancers With Different K-RAS Status. Front Endocrinol (Lausanne). 2019 Mar 12; 10:130. 4. Ashur-Fabian O, et, al. Tetrac Delayed the Onset of Ocular Melanoma in an Orthotopic Mouse Model. Front Endocrinol (Lausanne). 2019 Jan 8;9:775. 5. Rajabi M, et, al. Synthesis of new analogs of tetraiodothyroacetic acid (tetrac) as novel angiogenesis inhibitors for treatment of cancer. Bioorg Med Chem Lett. 2018 Apr 15;28(7):1223-1227.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Membrane Protein-targeted Compound Library Tyrosine Kinase Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compounds Library Max Bioactive Compound Library Immunology/Inflammation Compound Library Anti-Cancer Compound Library

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Keywords

Tetrac 67-30-1 Angiogenesis Apoptosis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR Tetraiodothyroacetic acid 3,3',5,5'-Tetraiodothyroacetic acid inhibitor inhibit

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