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hSMG-1 inhibitor 11e

Name: hSMG-1 inhibitor 11e
Brand: TargetMol
SKU: T35529
Price: 157 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T35529Cas No. 1402452-10-1

hSMG-1 inhibitor 11e is an effective and selective inhibitor of hSMG-1 (IC50 <0.05 nM) and can be used in studies about cancer treatment.

hSMG-1 inhibitor 11e

🥰Excellent

Purity: 99.89%

Catalog No. T35529Cas No. 1402452-10-1

hSMG-1 inhibitor 11e is an effective and selective inhibitor of hSMG-1 (IC50 <0.05 nM) and can be used in studies about cancer treatment.

Pack Size	Price	Availability
1 mg	$157	In Stock
5 mg	$396	In Stock
10 mg	$488	In Stock
25 mg	$787	In Stock
50 mg	$1,060	In Stock
1 mL x 10 mM (in DMSO)	$452	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.89%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	hSMG-1 inhibitor 11e is an effective and selective inhibitor of hSMG-1 (IC50 <0.05 nM) and can be used in studies about cancer treatment.
Targets&IC50	mTOR:45 nM (IC50), PI3Kγ:92 nM (IC50), CDK1:32 μM (IC50), SMG-1 (human):<0.05 nM (IC50), PI3Kα:61 nM (IC50), CDK2:7.1 μM (IC50)
In vitro	hSMG-1 inhibitor 11e exhibits an IC50 of 900-fold selectivity over mTOR (IC50 = 45 nM), PI3Kα/γ (IC50 = 61 nM), PI3Kγ (IC50 = 92 nM), CDK1(IC50 = 32 μM) and CDK2 (IC50 = 7.1 μM)[1].

Chemical Properties

Molecular Weight	517.6
Formula	C₂₆H₂₇N₇O₃S
Cas No.	1402452-10-1
Smiles	CNC(=O)Nc1ccc(cc1)-c1cc(ccn1)-c1ccnc(Nc2ccc(C)c(c2)S(=O)(=O)N(C)C)n1
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (86.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9320 mL	9.6600 mL	19.3199 mL	96.5997 mL
5 mM	0.3864 mL	1.9320 mL	3.8640 mL	19.3199 mL
10 mM	0.1932 mL	0.9660 mL	1.9320 mL	9.6600 mL
20 mM	0.0966 mL	0.4830 mL	0.9660 mL	4.8300 mL
50 mM	0.0386 mL	0.1932 mL	0.3864 mL	1.9320 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc