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TargetMol | Compound Library

EMA Approved Drug Library

Catalog No. L1020

New drug discovery is a highly resource-intensive, high-risk, and time-consuming endeavor. On average, it takes 10–15 years and costs several billion dollars to bring a novel therapeutic from target identification through lead optimization, preclinical studies, and multi-phase clinical trials. Moreover, the overall clinical failure rate exceeds 90%. Failures are particularly common in Phase II/III trials due to insufficient efficacy, safety concerns, or unfavorable pharmacokinetic properties—significantly limiting patient access to innovative therapies.
Against this backdrop, drug repurposing (also known as drug repositioning)—the strategy of identifying new therapeutic applications for already approved drugs beyond their original indications—has emerged as a key approach in modern drug development. Since these drugs have already undergone rigorous regulatory review, they possess well-established human safety profiles, favorable pharmacokinetic characteristics, and proven scalability in manufacturing. Repurposing them thus circumvents much of the uncertainty inherent in early-stage development and substantially accelerates translational success.
The EMA-Approved Drug Library contains 680 small-molecule compounds approved by the European Medicines Agency (EMA), spanning multiple therapeutic areas including oncology, cardiovascular diseases, neurological disorders, anti-infectives, immunomodulation, and endocrine/metabolic conditions. All compounds in the library have been clinically validated, with well-defined molecular targets, strong safety records, and good bioavailability—making them ideal candidates for drug repurposing. Leveraging this collection not only significantly enhances the likelihood of successful drug development but also shortens timelines and reduces overall R&D costs.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L1020

EMA Approved Drug Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 680 EMA-approved drugs for high throughput screening (HTS) and high content screening (HCS);
  • These compounds have undergone rigorous preclinical research and clinical trials, ensuring their bioactivity and safety;
  • Covers various research areas including oncology, cardiovascular, anti-inflammatory, immunological, neurological, respiratory drugs, and more;
  • More detailed compound information with structure, target, activity, IC50 value, and brief introduction;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Autophagy
Apoptosis
Antibacterial
Antibiotic
HIV Protease
Endogenous Metabolite
5-HT Receptor
Adrenergic Receptor
DNA/RNA Synthesis
c-Kit
VEGFR
Sodium Channel
PDGFR
Dopamine Receptor
Potassium Channel
Ferroptosis
SARS-CoV
Parasite
COX
Reverse Transcriptase
Virus Protease
Cytochromes P450
Calcium Channel
HCV Protease
FLT
EGFR
JAK
Antifungal
FGFR
Src
Histamine Receptor
Mitophagy
AChR
PDE
Bcr-Abl
Proteasome
Glucocorticoid Receptor
Nucleoside Antimetabolite/Analog
Topoisomerase
Raf
c-Met/HGFR
Estrogen/progestogen Receptor
Tyrosine Kinases
PPAR
HBV
RAAS
Serotonin Transporter
c-RET
SGLT
Thrombin
DPP-4
NF-κB
Influenza Virus
Estrogen Receptor/ERR
Transferase
MEK
PARP
ERK
Reactive Oxygen Species
ALK
TNF
Microtubule Associated
iGluR
CFTR
P-gp
ADC Cytotoxin
Dehydrogenase
TRP/TRPV Channel
Monoamine Oxidase
P2Y Receptor
ROS
Ras
S1P Receptor
Factor Xa
MAO
GABA Receptor
LPL Receptor
Antifolate
Androgen Receptor
HSV
ribosome
CDK
TAM Receptor
Prostaglandin Receptor
Molecular Glues
NMDAR
MMP
Progesterone Receptor
p38 MAPK
Norepinephrine
Trk receptor
Bcl-2 Family
ROS Kinase
Drug Metabolite
Thrombopoietin Receptor
ATPase
Carbonic Anhydrase
Hydroxylase
DHFR
Endothelin Receptor
Ligand for E3 Ligase
AMPK
Neurokinin receptor
Proton pump
Melatonin Receptor
Nrf2
Telomerase
STAT
Anti-infection
DNA Methyltransferase
Mitochondrial Metabolism
Angiotensin-converting Enzyme (ACE)
c-Fms
Adenosine Receptor
CaSR
HIF
Antifection
mTOR
HER
JNK
Smo
Hedgehog/Smoothened
Akt
Decarboxylase
IκB/IKK
MTP
PI3K
DNA Alkylator/Crosslinker
Phosphatase
Cysteine Protease
Guanylate cyclase
Opioid Receptor
Retinoid Receptor
NO Synthase
Kras
IKZF
PKC
ROCK
MT Receptor
Beta Amyloid
AhR
ROR
Amino Acids and Derivatives
Ligands for Target Protein for PROTAC
IL Receptor
OAT
RSV
Syk
HIF/HIF Prolyl-Hydroxylase
GPCR
Rho
PAK
Ephrin Receptor
GHSR
ASBT
Fatty Acid Synthase
Protease-activated Receptor
FAK
Antioxidant
ABC Transporter
CCR
GluR
Tie-2
Integrase
DNA Alkylation
Adenosine Deaminase
Chloride channel
FXR
Aryl Hydrocarbon Receptor
IRE1
DNA gyrase
Xanthine Oxidase
GluCls
FKBP
CGRP Receptor
Cannabinoid Receptor
BTK
YAP
IFNAR
Cell wall
Necroptosis
Hck
ACK1
CaMK
Antiviral
NOD-like Receptor (NLR)
Serine Protease
PAFR
HCAR
Chk
MAPK
Complement System
Arginase
gp120/CD4
GNRH Receptor
Photosensitizer
Isocitrate Dehydrogenase (IDH)
HCN Channel
Vasopressin Receptor
Lipoxygenase
GST
CRM1
UGT
BCRP
PGE Synthase
HMG-CoA Reductase
VDA
Monoamine Transporter
Cholinesterase (ChE)
IGF-1R
ATP Citrate Lyase
HDAC
CRISPR/Cas9
Sigma receptor
Imidazoline Receptor
NPC1L1
CSF-1R
Myosin
Glucosidase
Interleukin
TGF-beta/Smad
Beta-Secretase
Acyltransferase
Neprilysin
Phospholipase
Monocarboxylate transporter
Glutathione Peroxidase
Leukotriene Receptor
CXCR
TLR
NADPH-oxidase
Tyrosinase
PKM

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