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Anti-Phospho-MCM2 (Ser53) Polyclonal Antibody
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Catalog No. TMAB-10959
Anti-Phospho-MCM2 (Ser53) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MCM2 (Ser53). Anti-Phospho-MCM2 (Ser53) Polyclonal Antibody can be used in WB.
Anti-Phospho-MCM2 (Ser53) Polyclonal Antibody
Anti-Phospho-MCM2 (Ser53) Polyclonal Antibody
😃Good
Catalog No. TMAB-10959
Anti-Phospho-MCM2 (Ser53) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MCM2 (Ser53). Anti-Phospho-MCM2 (Ser53) Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-MCM2 (Ser53) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MCM2 (Ser53). Anti-Phospho-MCM2 (Ser53) Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Chicken,Dog,Pig,Horse,Rabbit,Zebrafish,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus (Probable). |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012] |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human MCM2 around the phosphorylation site of Ser53 |
| Antigen Species | Human |
| Gene Name | MCM2 |
| Gene ID | |
| Protein Name | DNA replication licensing factor MCM2 |
| Uniprot ID | |
| Function | Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. |
| Molecular Weight | Theoretical: 101 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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