keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NX-2127 (ETX2514 Triethylamine) is an orally active BTK inhibitor that induces degradation of mutant BTKC481S in cells.NX-2127 has potent antiproliferative activity and inhibits the proliferation of BTKC481S mutant TMD8 cells.NX-2127 potently catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) at 25 nM and 54 nM, respectively. NX-2127 is associated with the immune system, stimulating T cell activation and increasing IL-2 production in primary human T cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 109.00 | |
5 mg | In stock | $ 272.00 | |
10 mg | In stock | $ 428.00 | |
25 mg | In stock | $ 713.00 | |
50 mg | In stock | $ 987.00 | |
100 mg | In stock | $ 1,360.00 | |
500 mg | In stock | $ 2,730.00 |
Description | NX-2127 (ETX2514 Triethylamine) is an orally active BTK inhibitor that induces degradation of mutant BTKC481S in cells.NX-2127 has potent antiproliferative activity and inhibits the proliferation of BTKC481S mutant TMD8 cells.NX-2127 potently catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) at 25 nM and 54 nM, respectively. NX-2127 is associated with the immune system, stimulating T cell activation and increasing IL-2 production in primary human T cells. |
Synonyms | NX2127, NX 2127 |
Molecular Weight | 719.83 |
Formula | C39H45N9O5 |
CAS No. | 2416131-46-7 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (69.46 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NX-2127 2416131-46-7 Angiogenesis Tyrosine Kinase/Adaptors BTK NX2127 NX 2127 inhibitor inhibit