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NX-2127 (ETX2514 Triethylamine) is an orally active BTK inhibitor that induces degradation of mutant BTKC481S in cells.NX-2127 has potent antiproliferative activity and inhibits the proliferation of BTKC481S mutant TMD8 cells.NX-2127 potently catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) at 25 nM and 54 nM, respectively. NX-2127 is associated with the immune system, stimulating T cell activation and increasing IL-2 production in primary human T cells.

| Pack Size | Price | Availability | Quantity | 
|---|---|---|---|
| 1 mg | $105 | In Stock | |
| 5 mg | $259 | In Stock | |
| 10 mg | $389 | In Stock | |
| 25 mg | $713 | In Stock | |
| 50 mg | $987 | In Stock | |
| 100 mg | $1,360 | In Stock | |
| 200 mg | $1,830 | In Stock | 
| Description | NX-2127 (ETX2514 Triethylamine) is an orally active BTK inhibitor that induces degradation of mutant BTKC481S in cells.NX-2127 has potent antiproliferative activity and inhibits the proliferation of BTKC481S mutant TMD8 cells.NX-2127 potently catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) at 25 nM and 54 nM, respectively. NX-2127 is associated with the immune system, stimulating T cell activation and increasing IL-2 production in primary human T cells. | 
| Synonyms | NX2127, NX 2127 | 
| Molecular Weight | 719.83 | 
| Formula | C39H45N9O5 | 
| Cas No. | 2416131-46-7 | 
| Smiles | O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=C(C2)N4C[C@H](CN5CCC(CC5)C6=CC=C(NC=7C(C(N)=O)=NC=C(N7)N8CCCCC8)C=C6)CC4 | 
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 150 mg/mL (208.38 mM), Sonication is recommended.   | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 2% DMSO+40% PEG300+5% Tween 80+53% Saline: 3 mg/mL (4.17 mM), Suspension. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.  | |||||||||||||||||||||||||||||||||||
| Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
| DMSO 
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 For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL .
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL .  A total of 10 animals were administered, and the formula you used is 5%
 A total of 10 animals were administered, and the formula you used is 5%  DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。 (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
 (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first. main solution, add 300 μLPEG300
 main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O
 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
 mix well and clarify
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