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Anti-Phospho-PAK1/2/3 (Ser144/Ser141/Ser154) Antibody (1J605)
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Catalog No. TMAB-11103
Anti-Phospho-PAK1/2/3 (Ser144/Ser141/Ser154) Antibody (1J605) is a Rabbit antibody targeting Phospho-PAK1/2/3 (Ser144/Ser141/Ser154). Anti-Phospho-PAK1/2/3 (Ser144/Ser141/Ser154) Antibody (1J605) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,IP,FCM.
Anti-Phospho-PAK1/2/3 (Ser144/Ser141/Ser154) Antibody (1J605)
Anti-Phospho-PAK1/2/3 (Ser144/Ser141/Ser154) Antibody (1J605)
😃Good
Catalog No. TMAB-11103
Anti-Phospho-PAK1/2/3 (Ser144/Ser141/Ser154) Antibody (1J605) is a Rabbit antibody targeting Phospho-PAK1/2/3 (Ser144/Ser141/Ser154). Anti-Phospho-PAK1/2/3 (Ser144/Ser141/Ser154) Antibody (1J605) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,IP,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $149 | 7-10 days | 7-10 days | |
| 50 μL | $262 | 7-10 days | 7-10 days | |
| 100 μL | $470 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-PAK1/2/3 (Ser144/Ser141/Ser154) Antibody (1J605) is a Rabbit antibody targeting Phospho-PAK1/2/3 (Ser144/Ser141/Ser154). Anti-Phospho-PAK1/2/3 (Ser144/Ser141/Ser154) Antibody (1J605) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,IP,FCM. |
| Ig Type | IgG |
| Clone | 1J605 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-5000; IHC-P: 1:100-200; IHC-Fr: 1:100-200; ICC/IF: 1:50-200; IF: 1:100-200; IP: 1:20-50; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Cell junction, focal adhesion. Note=Recruited to focal adhesions upon activation. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. |
| Immunogen | A synthesized peptide: human PAK1 around the phosphorylation site of S144 |
| Antigen Species | Human |
| Gene Name | PAK1 |
| Gene ID | |
| Protein Name | Serine/threonine-protein kinase PAK 1 |
| Uniprot ID | |
| Function | The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2. |
| Molecular Weight | Theoretical: 58-62 kDa. Actual: 65 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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