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GITR/TNFRSF18 Protein, Human, Recombinant (His)

Catalog No. TMPY-00072
GITR/TNFRSF18 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is Q9Y5U5-3.
Pack SizePriceAvailabilityQuantity
100 μg$296In Stock
200 μg$5377-10 days
500 μg$1,1707-10 days
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Product Information

Biological Activity
Measured by its binding ability in a functional ELISA. Immobilized TNFRSF18-His at 10 μg/mL (100 μL/well) can bind TNFSF18-mFc , the EC50 of TNFSF18-mFc is 20-60 ng/mL.
GITR/TNFRSF18 Protein, Human, Recombinant (His)
Description
GITR/TNFRSF18 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is Q9Y5U5-3.
Species
Human
Expression System
HEK293 Cells
TagC-His
Accession NumberQ9Y5U5-3
Synonyms
tumor necrosis factor receptor superfamily, member 18,GITR-D,GITR,CD357,AITR
Construction
A DNA sequence encoding the human TNFRSF18 (NP_683700.1) (Met1-Glu161) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Gln 26
Protein Purity
> 95 % as determined by SDS-PAGE.
GITR/TNFRSF18 Protein, Human, Recombinant (His)
Molecular Weight16 kDa (predicted); 25.44 kDa (reducing condition, due to glycosylation)
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice.
Research Background
GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy

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