GITR/TNFRSF18 Protein, Human, Recombinant (His)

Name: GITR/TNFRSF18 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-00072
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: tumor necrosis factor receptor superfamily, member 18, GITR-D, GITR, CD357, AITR) Copy Product Info

Synonyms: tumor necrosis factor receptor superfamily, member 18, GITR-D, GITR, CD357, AITR

Catalog No. TMPY-00072 Copy Product Info

Purity: 97%

GITR/TNFRSF18 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is Q9Y5U5-3.

Pack Size	Price	USA Stock	Global Stock
5 µg	$39	-	In Stock
10 µg	$59	-	In Stock
20 µg	$93	-	In Stock
50 µg	$178	-	In Stock
100 µg	$296	-	In Stock
200 µg	$537	7-10 days	7-10 days
500 µg	$1,170	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Information

Bioactivity

Bioactivity	Measured by its binding ability in a functional ELISA. Immobilized TNFRSF18-His at 10 μg/mL (100 μL/well) can bind TNFSF18-mFc , the EC50 of TNFSF18-mFc is 20-60 ng/mL.
Description	GITR/TNFRSF18 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is Q9Y5U5-3.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q9Y5U5-3
Construction	A DNA sequence encoding the human TNFRSF18 (NP_683700.1) (Met1-Glu161) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Gln 26
Protein Purity	> 95 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	tumor necrosis factor receptor superfamily, member 18, GITR-D, GITR, CD357, AITR
Research Background	GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

16 kDa (predicted); 25.44 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.