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Cilgavimab

(Synonyms: COV2-2130, COV22130, AZD5156, AZD-1061, AZD1061, AZD 5156) Copy Product Info
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Synonyms: COV2-2130, COV22130, AZD5156, AZD-1061, AZD1061, AZD 5156

Catalog No. T76999 Copy Product Info
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Cilgavimab (AZD-1061) is a humanized monoclonal antibody targeting the spike protein of SARS-CoV-2, used in studies of COVID-19 infection.
Cilgavimab
Cas No. 2420563-99-9
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Pack SizePriceUSA StockGlobal StockQuantity
1 mg$247In StockIn Stock
5 mg$645In StockIn Stock
10 mg$987-In Stock
25 mg$1,530-In Stock
50 mg$1,980-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:99.35% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction

Bioactivity
Description
Cilgavimab (AZD-1061) is a humanized monoclonal antibody targeting the spike protein of SARS-CoV-2, used in studies of COVID-19 infection.
In vitro
Cilgavimab has strong monoclonal antibody neutralization activity and human ACE2 blocking activity with IC50 of 10-150 ng/mL.
Cilgavimab can bind to trimer S2Pecto protein or monomer SRBD protein with IC50 of 0.1-10 ng/mL. [1]
In vivo
In a mouse model of SARS-CoV-2 infection, Cilgavimab (200 μg/ dose) treatment reduced the expression of inflammatory cytokine and chemokine genes in the lungs of the mice, reducing viral burden and lung inflammation levels. [1]
SynonymsCOV2-2130, COV22130, AZD5156, AZD-1061, AZD1061, AZD 5156
Reactivity
Virus
Application
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Gene ID
Uniprot ID
TargetSpike RBD
Chemical Properties
Molecular Weight148.54 kDa
Cas No.2420563-99-9
Antibody Information
IsotypeHuman IgG1 kappa
Recommended Isotype Control
Storage & Solubility Information
StorageStore at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: Cilgavimab chemical structure | Cilgavimab in vivo | Cilgavimab in vitro | Cilgavimab molecular weight