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Posdinemab (Synonyms: JNJ-63733657, JNJ63733657, JNJ 63733657)
Catalog No. T80616 Copy Product Info
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Posdinemab (JNJ-63733657) is a humanized monoclonal antibody targeting pT217 phosphorylated Tau. By specifically binding to pathological Tau, it blocks its propagation and aggregation between neurons, thereby delaying the progression of Alzheimer's and other tauopathies.
Posdinemab
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Catalog No. T80616
Synonyms JNJ-63733657, JNJ63733657, JNJ 63733657
Posdinemab (JNJ-63733657) is a humanized monoclonal antibody targeting pT217 phosphorylated Tau. By specifically binding to pathological Tau, it blocks its propagation and aggregation between neurons, thereby delaying the progression of Alzheimer's and other tauopathies.
Posdinemab
Cas No. 2517973-04-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | - | In Stock | |
| 5 mg | $647 | - | In Stock | |
| 10 mg | $987 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:96.4% (SDS-PAGE); 95.2% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Posdinemab (JNJ-63733657) is a humanized monoclonal antibody targeting pT217 phosphorylated Tau. By specifically binding to pathological Tau, it blocks its propagation and aggregation between neurons, thereby delaying the progression of Alzheimer's and other tauopathies. |
| In vitro | In experiments using artificial cerebrospinal fluid and mouse brain homogenates, immunoprecipitation with 100 nM Posdinemab followed by 20 hours of enzymatic digestion, and subsequent analysis by LC-MS, demonstrated that it specifically enriches the diphosphorylated Tau peptide (SRTPSLPTPPTREPK2p) containing the pT217 site, confirming that this antibody exhibits extremely high affinity and precise selective capture capacity for pathologically phosphorylated tau protein [2]. |
| Synonyms | JNJ-63733657, JNJ63733657, JNJ 63733657 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | MAPT |
| Molecular Weight | 145.34 kDa |
| Cas No. | 2517973-04-3 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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