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(S)-Coriolic acid

Catalog No. T37974 CAS 29623-28-7

Synonyms: 13(S)-HODE

(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent, generated by the reaction of linoleic acid with plant and mammalian lipoxygenases, and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid inhibits the adhesion of tumor cells to the vascular endothelium and down-regulates the expression of IRGpIIb/IIIa receptors at around 1 μM. (S)-Coriolic acid is a metabolite of 15-lipoxygenase (15-LOX), which often acts as an endogenous ligand to activate PPARγ. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial damage.

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(S)-Coriolic acid, CAS 29623-28-7

Pack Size	Availability	Price/USD
100 μg	In stock	$ 145.00
250 μg	In stock	$ 326.00
500 μg	In stock	$ 489.00
1 mg	In stock	$ 733.00
5 mg	In stock	$ 1,390.00

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Purity: 97.11%

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Chemical Properties

Storage & Solubility Information

Description	(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent, generated by the reaction of linoleic acid with plant and mammalian lipoxygenases, and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid inhibits the adhesion of tumor cells to the vascular endothelium and down-regulates the expression of IRGpIIb/IIIa receptors at around 1 μM. (S)-Coriolic acid is a metabolite of 15-lipoxygenase (15-LOX), which often acts as an endogenous ligand to activate PPARγ. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial damage.
In vitro	(S)-Coriolic acid (30 nM; 6 h; E-FABP-/- keratinocytes) induces K1 expression through NF-κB activation. (S)-Coriolic acid also increases the phosphorylation of Ikkinase-bat tyrosine 199, which promotes IκBα phosphorylation and subsequent NF-kB activation. (S)-Coriolic acid increases the phosphorylation of IκBαat serine 32, which induces IκB degradation and thereby activates NF-κB.[3]
In vivo	(S)-Coriolic acid (0-0.6 mg; Intranasal; once a day for 3 consecutive days; mouse) induces pronounced airway dysfunction, airway neutrophilia, mitochondrial dysfunction, and epithelial injury.[2]

Synonyms	13(S)-HODE
Molecular Weight	296.44
Formula	C18H32O3
CAS No.	29623-28-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: >50 mg/mL (per Rao Maddipati)

DMSO: 55 mg/mL (185.54 mM)

PBS (pH 7.2): 1 mg/mL

DMF: >50 mg/mL (per Rao Maddipati)

References and Literature

1. Mabalirajan U, et al. Linoleic acid metabolite drives severe asthma by causing airway epithelial injury. Sci Rep. 2013;3:1349. 2. Ogawa E, et al. Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-κB signaling pathway. J Invest Dermatol. 2011;131(3):604-612. 3. Yuan H, et al. 15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer. Thorax. 2010;65(4):321-326. 4. Buchanan MR, et al. 13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX. J Biol Chem. 1985;260(30):16056-16059. 5. Honn KV, et al. Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasis. Prostaglandins. 1992;44(5):413-429.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Natural Product Library for HTS Bioactive Compounds Library Max Traditional Chinese Medicine Monomer Library Food as Medicine Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Selected Plant-Sourced Compound Library Bioactive Compound Library Tibetan medicine Compound Library

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Keywords

(S)-Coriolic acid 29623-28-7 DNA Damage/DNA Repair Metabolism Lipoxygenase PPAR Mitochondrial Metabolism 13HODE Coriolic acid 13(S)-HODE inhibitor inhibit

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