Shopping Cart

Your shopping cart is currently empty

(S)-Coriolic acid

Name: (S)-Coriolic acid
Brand: TargetMol
SKU: T37974
Price: 389 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T37974Cas No. 29623-28-7

Alias 13(S)-HODE

(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent generated by the reaction of linoleic acid with plant and mammalian lipoxygenases. It is involved in cell proliferation and differentiation in various biological systems and inhibits the adhesion of tumor cells to the vascular endothelium, while down-regulating IRGpIIb/IIIa receptor expression at around 1 μM. Additionally, (S)-Coriolic acid is a metabolite of 15-lipoxygenase (15-LOX) and often acts as an endogenous ligand to activate PPARγ. It induces mitochondrial dysfunction and airway epithelial damage.

(S)-Coriolic acid

Copy Product Info

😃Good

Purity: 98.04%

Catalog No. T37974Alias 13(S)-HODECas No. 29623-28-7

Pack Size	Price	USA Warehouse	Global Warehouse
100 ug (337.33 μM* 1 mL in Ethanol)	$389	-	In Stock
250 ug (337.33 μM * 2.5 mL in Ethanol)	$780	-	In Stock
500 ug (337.33 μM * 5 mL in Ethanol)	$1,450	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.04%

Color:Transparent to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent generated by the reaction of linoleic acid with plant and mammalian lipoxygenases. It is involved in cell proliferation and differentiation in various biological systems and inhibits the adhesion of tumor cells to the vascular endothelium, while down-regulating IRGpIIb/IIIa receptor expression at around 1 μM. Additionally, (S)-Coriolic acid is a metabolite of 15-lipoxygenase (15-LOX) and often acts as an endogenous ligand to activate PPARγ. It induces mitochondrial dysfunction and airway epithelial damage.
In vitro	(S)-Coriolic acid (30 nM; 6 h; E-FABP-/- keratinocytes) induces K1 expression through NF-κB activation. (S)-Coriolic acid also increases the phosphorylation of Ikkinase-bat tyrosine 199, which promotes IκBα phosphorylation and subsequent NF-kB activation. (S)-Coriolic acid increases the phosphorylation of IκBαat serine 32, which induces IκB degradation and thereby activates NF-κB.[3]
In vivo	(S)-Coriolic acid (0-0.6 mg; intranasal; once daily for 3 consecutive days; mouse) induces significant airway dysfunction, neutrophilia, mitochondrial dysfunction, and epithelial injury.[2]
Synonyms	13(S)-HODE

Chemical Properties

Molecular Weight	296.44
Formula	C₁₈H₃₂O₃
Cas No.	29623-28-7
Smiles	C(=C/C=C\CCCCCCCC(O)=O)\[C@H](CCCCC)O
Relative Density.	0.970 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: >50 mg/mL (per Rao Maddipati), Sonication is recommended.

DMSO: 55 mg/mL (185.54 mM), Sonication is recommended.

PBS (pH 7.2): 1 mg/mL (3.37 mM), Sonication is recommended.

DMF: >50 mg/mL (per Rao Maddipati), Sonication is recommended.

Solution Preparation Table

PBS (pH 7.2)/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3734 mL	16.8668 mL	33.7336 mL	168.6682 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.6747 mL	3.3734 mL	6.7467 mL	33.7336 mL
10 mM	0.3373 mL	1.6867 mL	3.3734 mL	16.8668 mL
20 mM	0.1687 mL	0.8433 mL	1.6867 mL	8.4334 mL
50 mM	0.0675 mL	0.3373 mL	0.6747 mL	3.3734 mL
100 mM	0.0337 mL	0.1687 mL	0.3373 mL	1.6867 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc