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Tolmetin sodium dihydrate

Name: Tolmetin sodium dihydrate
Brand: TargetMol
SKU: T2550L
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2550LCas No. 64490-92-2

Tolmetin sodium dihydrate is a potent non-steroidal anti-inflammatory drug (NSAID) that acts as an orally active cyclooxygenase (COX) inhibitor. Tolmetin sodium dihydrate demonstrates inhibitory concentration (IC50) values of 0.35 μM and 0.82 μM for human COX-1 and COX-2 enzymes, respectively, and is widely used as a reference compound for studying the biochemical and pharmacodynamic properties of NSAID-mediated prostaglandin synthesis inhibition.

Tolmetin sodium dihydrate

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Purity: 99.57%

Catalog No. T2550LCas No. 64490-92-2

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	-	In Stock
100 mg	$37	-	In Stock
500 mg	$79	-	In Stock
1 g	$113	-	In Stock
1 mL x 10 mM (in DMSO)	$39	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.57%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Tolmetin sodium dihydrate is a potent non-steroidal anti-inflammatory drug (NSAID) that acts as an orally active cyclooxygenase (COX) inhibitor. Tolmetin sodium dihydrate demonstrates inhibitory concentration (IC50) values of 0.35 μM and 0.82 μM for human COX-1 and COX-2 enzymes, respectively, and is widely used as a reference compound for studying the biochemical and pharmacodynamic properties of NSAID-mediated prostaglandin synthesis inhibition.
Targets&IC50	COX-2 (human):0.82 μM, COX-1 (human):0.35 μM
In vitro	Tolmetin sodium dihydrate (0.25 mM) showed no inhibitory effect on lipid peroxidation in rat brain homogenates [3]. Tolmetin sodium dihydrate (0.001-100 μM) exhibited dose-dependent anticancer activity against HT-29 colon carcinoma cells [4]. Tolmetin sodium dihydrate (0-100 μM) had no significant effect on osteoblast growth [5].
In vivo	In male Wistar rats, the ulcerogenic effect of Tolmetin sodium dihydrate (30, 100 mg/kg, oral administration) reached its peak 4 hours after a single dose, while this effect significantly weakened after repeated administration for 3 and 14 days [2]. Pretreatment with Tolmetin sodium dihydrate (5 mg/kg, twice daily) for 5 consecutive days effectively alleviated quinolinic acid (QA)-induced neurotoxicity [3].

Chemical Properties

Molecular Weight	315.3
Formula	C₁₅H₁₈NNaO₅
Cas No.	64490-92-2
Smiles	O=C(CC1=CC=C(N1C)C(C2=CC=C(C)C=C2)=O)[O-].[Na+].O.O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (31.72 mM), Sonication is recommended.

H2O: ≥ 80 mg/mL, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (3.17 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1716 mL	15.8579 mL	31.7158 mL	158.5791 mL
5 mM	0.6343 mL	3.1716 mL	6.3432 mL	31.7158 mL
10 mM	0.3172 mL	1.5858 mL	3.1716 mL	15.8579 mL
20 mM	0.1586 mL	0.7929 mL	1.5858 mL	7.9290 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc