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Tolmetin sodium dihydrate

Name: Tolmetin sodium dihydrate
Brand: TargetMol
SKU: T2550L
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2550LCas No. 64490-92-2

Tolmetin sodium dihydrate is a potent non-steroidal anti-inflammatory drug (NSAID) that acts as an orally active cyclooxygenase (COX) inhibitor. Tolmetin sodium dihydrate demonstrates inhibitory concentration (IC50) values of 0.35 μM and 0.82 μM for human COX-1 and COX-2 enzymes, respectively, and is widely used as a reference compound for studying the biochemical and pharmacodynamic properties of NSAID-mediated prostaglandin synthesis inhibition.

Tolmetin sodium dihydrate

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Purity: 99.57%

Catalog No. T2550LCas No. 64490-92-2

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	-	In Stock
100 mg	$37	-	In Stock
500 mg	$79	-	In Stock
1 g	$113	-	In Stock
1 mL x 10 mM (in DMSO)	$39	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.57%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Tolmetin sodium dihydrate is a potent non-steroidal anti-inflammatory drug (NSAID) that acts as an orally active cyclooxygenase (COX) inhibitor. Tolmetin sodium dihydrate demonstrates inhibitory concentration (IC50) values of 0.35 μM and 0.82 μM for human COX-1 and COX-2 enzymes, respectively, and is widely used as a reference compound for studying the biochemical and pharmacodynamic properties of NSAID-mediated prostaglandin synthesis inhibition.
Targets&IC50	COX-2 (human):0.82 μM, COX-1 (human):0.35 μM
In vitro	Tolmetin sodium dihydrate (0.25 mM) showed no inhibitory effect on lipid peroxidation in rat brain homogenates [3]. Tolmetin sodium dihydrate (0.001-100 μM) exhibited dose-dependent anticancer activity against HT-29 colon carcinoma cells [4]. Tolmetin sodium dihydrate (0-100 μM) had no significant effect on osteoblast growth [5].
In vivo	In male Wistar rats, the ulcerogenic effect of Tolmetin sodium dihydrate (30, 100 mg/kg, oral administration) reached its peak 4 hours after a single dose, while this effect significantly weakened after repeated administration for 3 and 14 days [2]. Pretreatment with Tolmetin sodium dihydrate (5 mg/kg, twice daily) for 5 consecutive days effectively alleviated quinolinic acid (QA)-induced neurotoxicity [3].

Chemical Properties

Molecular Weight	315.3
Formula	C₁₅H₁₈NNaO₅
Cas No.	64490-92-2
Smiles	O=C(CC1=CC=C(N1C)C(C2=CC=C(C)C=C2)=O)[O-].[Na+].O.O
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (31.72 mM), Sonication is recommended.

H2O: ≥ 80 mg/mL, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (3.17 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1716 mL	15.8579 mL	31.7158 mL	158.5791 mL
5 mM	0.6343 mL	3.1716 mL	6.3432 mL	31.7158 mL
10 mM	0.3172 mL	1.5858 mL	3.1716 mL	15.8579 mL
20 mM	0.1586 mL	0.7929 mL	1.5858 mL	7.9290 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc