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GLP-1(7-37) acetate(106612-94-6 free base)

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Catalog No. TP1376Cas No. 1450806-98-0
Alias GLP-1(7-37) acetate

Glp-1(7-37) acetate is an intestinal insulin hormone that enhances glucose-induced insulin secretion.

GLP-1(7-37) acetate(106612-94-6 free base)

GLP-1(7-37) acetate(106612-94-6 free base)

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Purity: 98.89%
Catalog No. TP1376Alias GLP-1(7-37) acetateCas No. 1450806-98-0
Glp-1(7-37) acetate is an intestinal insulin hormone that enhances glucose-induced insulin secretion.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$98In StockIn Stock
5 mg$228In StockIn Stock
10 mg$347In StockIn Stock
25 mg$589In StockIn Stock
50 mg$842In StockIn Stock
100 mg$1,160In StockIn Stock
200 mg$1,560-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.89%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Glp-1(7-37) acetate is an intestinal insulin hormone that enhances glucose-induced insulin secretion.
In vivo
GLP-1(7-37) (0.5, 5, or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of glucose-stimulated plasma insulin concentration and an increased glucose infusion rate in rats[2]. Continuous infusion of GLP-1(7-37) (5 pmol/min/kg) from 1 to 7 hours maintains a sustained increase in plasma insulin levels compared to vehicle-infused rats with glucose concentration held at 11 mM[2].
SynonymsGLP-1(7-37) acetate
Chemical Properties
Molecular Weight3355.67
FormulaC151H228N40O47
Cas No.1450806-98-0
SmilesO=C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CCCNC(N)=N)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC6=CNC=N6)N
Relative Density.no data available
SequenceHis-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly
Sequence ShortHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 6.71 mg/mL (2 mM), Sonication and heating are recommended.
H2O: 81.7 mg/mL (24.35 mM), , when pH is adjusted to 1 with HCl. Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM0.2980 mL1.4900 mL2.9800 mL14.9002 mL
H2O
1mg5mg10mg50mg
5 mM0.0596 mL0.2980 mL0.5960 mL2.9800 mL
10 mM0.0298 mL0.1490 mL0.2980 mL1.4900 mL
20 mM0.0149 mL0.0745 mL0.1490 mL0.7450 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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