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LY223982

Name: LY223982
Brand: TargetMol
SKU: T15803
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15803Cas No. 117423-74-2

Alias SKF107324, LY-223982, CGS23131

LY223982 is an effective and selective LTB4 (leukotriene B4 receptor) antagonist that inhibits LTB4-induced neutrophil activation and transient leukopenia.

LY223982

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Purity: 99.86%

Catalog No. T15803Alias SKF107324, LY-223982, CGS23131Cas No. 117423-74-2

LY223982 is an effective and selective LTB4 (leukotriene B4 receptor) antagonist that inhibits LTB4-induced neutrophil activation and transient leukopenia.

Pack Size	Price	Availability
1 mg	$42	In Stock
5 mg	$98	In Stock
10 mg	$147	In Stock
25 mg	$268	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock

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Purity:99.86%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	LY223982 is an effective and selective LTB4 (leukotriene B4 receptor) antagonist that inhibits LTB4-induced neutrophil activation and transient leukopenia.
Targets&IC50	LTB4:13.2 nM
In vitro	LY223982 is 189-fold more efficient than 35S-N-formyl-L-formyl-L-leucyl-L-phenylalanine (FMLP) in displacing [3H]LTB4 from its corresponding receptor on human neutrophils. The concentration that inhibits [3H]LTB4 displacement by 50% (IC50 value of 13.2 nM) is only 6.8-fold higher than that of non-radioactive LTB4.[1]
In vivo	LY223982 inhibits transient leukopenia induced by LTB4 (ED50, 3 mg/kg) in rabbits, but not by FMLP. LY223982 has no agonist activity in any test system.[1]
Synonyms	SKF107324, LY-223982, CGS23131

Chemical Properties

Molecular Weight	502.56
Formula	C₃₀H₃₀O₇
Cas No.	117423-74-2
Smiles	C(CC(O)=O)C1=C(OCCCC/C=C/C2=CC=C(OC)C=C2)C=CC(C(=O)C3=CC(C(O)=O)=CC=C3)=C1
Relative Density.	1.235 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (159.18 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9898 mL	9.9491 mL	19.8981 mL	99.4906 mL
5 mM	0.3980 mL	1.9898 mL	3.9796 mL	19.8981 mL
10 mM	0.1990 mL	0.9949 mL	1.9898 mL	9.9491 mL
20 mM	0.0995 mL	0.4975 mL	0.9949 mL	4.9745 mL
50 mM	0.0398 mL	0.1990 mL	0.3980 mL	1.9898 mL
100 mM	0.0199 mL	0.0995 mL	0.1990 mL	0.9949 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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