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Fructosyl-lysine

Name: Fructosyl-lysine
Brand: TargetMol
SKU: T15350
Rating: 4.5 (1 reviews)

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Catalog No. T15350Cas No. 21291-40-7

Alias Fructoselysine

Fructosyl-lysine is the precursor to glucosepane. Fructosyl-lysine is a lysine–arginine protein cross-link that can be an indicator in diabetes detection. Fructosyl-lysine is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction.

Fructosyl-lysine

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Catalog No. T15350Alias FructoselysineCas No. 21291-40-7

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$954	6-8 weeks	6-8 weeks
50 mg	$1,240	6-8 weeks	6-8 weeks
100 mg	$1,740	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Fructosyl-lysine is the precursor to glucosepane. Fructosyl-lysine is a lysine–arginine protein cross-link that can be an indicator in diabetes detection. Fructosyl-lysine is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction.
In vitro	Fructosyl-lysine (100 μM; 1 hour) contains a carbohydrate moiety and appears to be phosphorylated, it can be converted to glucose 6-phosphate in bacterial extracts in?E?.coli extracts. Fructosyl-lysine (25 mM; 25 hours) lets E. coli?growth at a rate of about one-third of that observed with glucose as a carbon source. Fructosyl-lysine (5 mM; 0.5 hours) catalyzes the ATP-dependent conversion of [14C]fructoselysine to anionic products showing the existence of a fructoselysine-kinase activity in E?.coli extracts [2].
In vivo	In diabetic rats, Fructosyl-lysine and AGE residues are increased markedly in glomeruli, sciatic nerve, retina, and plasma protein [1].
Synonyms	Fructoselysine

Chemical Properties

Molecular Weight	308.33
Formula	C₁₂H₂₄N₂O₇
Cas No.	21291-40-7
Smiles	C([C@H]([C@@H]([C@@H](CO)O)O)O)(CNCCCC[C@@H](C(O)=O)N)=O
Relative Density.	1.386 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 40 mg/mL (129.73 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.2433 mL	16.2164 mL	32.4328 mL	162.1639 mL
5 mM	0.6487 mL	3.2433 mL	6.4866 mL	32.4328 mL
10 mM	0.3243 mL	1.6216 mL	3.2433 mL	16.2164 mL
20 mM	0.1622 mL	0.8108 mL	1.6216 mL	8.1082 mL
50 mM	0.0649 mL	0.3243 mL	0.6487 mL	3.2433 mL
100 mM	0.0324 mL	0.1622 mL	0.3243 mL	1.6216 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc