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ZNL 02-096

Catalog No. T41163 CAS 2414418-49-6

Synonyms: Pomalidomide-C3-adavosertib

ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a secondary target of AZD 1775.ZNL 02-096 induces degradation of Wee1 and accumulation of DNA damage in MOLT-4 cells in vitro, In vitro in MOLT-4 cells, ZNL 02-096 induced Wee1 degradation, accumulation of DNA damage, cell cycle arrest in G2/M phase and apoptosis.ZNL 02-096 showed anti-proliferative effects in 300 cancer cell lines.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

ZNL 02-096, CAS 2414418-49-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 350.00
5 mg	In stock	$ 828.00
10 mg	In stock	$ 1,130.00
25 mg	In stock	$ 1,590.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,500.00
500 mg	In stock	$ 4,900.00

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Purity: 99.84%

Purity: 98.71%

Biological Description

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Description

In vitro

ZNL 02-096 (1 nM-10 μM; 24, 48, and 72 h; OVCAR8, COV362, and Kuramochi cells) induces CRBN-dependent anti-proliferative effects and synergizes with Olaparib. ZNL 02-096 (6 h) degrades Wee1 in OVCAR8 cells, with maximal degradation observed at a 100 nM treatment.[1]
ZNL 02-096 (100 nM; 24 h) induces DNA damage, apoptosis, and deregulation of the G2/M checkpoint.[1]

Synonyms	Pomalidomide-C3-adavosertib
Molecular Weight	799.88
Formula	C42H45N11O6
CAS No.	2414418-49-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Nathanael S G, et al. Degraders of wee1 kinase. WO2020069105A1.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Bioactive Compound Library Bioactive Compounds Library Max Kinase Inhibitor Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets

6-Thioguanine Bendamustine hydrochloride VPC-70063 Selonsertib Tiplaxtinin Simmiparib Calycosin Kaerophyllin

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ZNL 02-096 2414418-49-6 Apoptosis Cell Cycle/Checkpoint Wee1 Pomalidomide-C3-adavosertib inhibitor inhibit

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