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ZNL 02-096

Name: ZNL 02-096
Brand: TargetMol
SKU: T41163
Price: 263 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T41163Cas No. 2414418-49-6

Alias Pomalidomide-C3-adavosertib

ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a secondary target of AZD 1775.ZNL 02-096 induces degradation of Wee1 and accumulation of DNA damage in MOLT-4 cells in vitro, In vitro in MOLT-4 cells, ZNL 02-096 induced Wee1 degradation, accumulation of DNA damage, cell cycle arrest in G2/M phase and apoptosis.ZNL 02-096 showed anti-proliferative effects in 300 cancer cell lines.

ZNL 02-096

🥰Excellent

Purity: 99.84%

Catalog No. T41163Alias Pomalidomide-C3-adavosertibCas No. 2414418-49-6

Pack Size	Price	Availability
1 mg	$263	In Stock
2 mg	$392	In Stock
5 mg	$668	In Stock
10 mg	$892	In Stock
25 mg	$1,350	In Stock
50 mg	$1,820	In Stock
100 mg	$2,450	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.84%

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COA FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a secondary target of AZD 1775.ZNL 02-096 induces degradation of Wee1 and accumulation of DNA damage in MOLT-4 cells in vitro, In vitro in MOLT-4 cells, ZNL 02-096 induced Wee1 degradation, accumulation of DNA damage, cell cycle arrest in G2/M phase and apoptosis.ZNL 02-096 showed anti-proliferative effects in 300 cancer cell lines.
In vitro	ZNL 02-096 (1 nM-10 μM; 24, 48, and 72 h; OVCAR8, COV362, and Kuramochi cells) induces CRBN-dependent anti-proliferative effects and synergizes with Olaparib. ZNL 02-096 (6 h) degrades Wee1 in OVCAR8 cells, with maximal degradation observed at a 100 nM treatment.[1] ZNL 02-096 (100 nM; 24 h) induces DNA damage, apoptosis, and deregulation of the G2/M checkpoint.[1]
Synonyms	Pomalidomide-C3-adavosertib

Chemical Properties

Molecular Weight	799.88
Formula	C₄₂H₄₅N₁₁O₆
Cas No.	2414418-49-6
Smiles	C(C=C)N1N(C=2C(C1=O)=CN=C(NC3=CC=C(C=C3)N4CCN(CCCNC5=C6C(C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=CC=C5)CC4)N2)C=8N=C(C(C)(C)O)C=CC8
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (62.51 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.25 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2502 mL	6.2509 mL	12.5019 mL	62.5094 mL
5 mM	0.2500 mL	1.2502 mL	2.5004 mL	12.5019 mL
10 mM	0.1250 mL	0.6251 mL	1.2502 mL	6.2509 mL
20 mM	0.0625 mL	0.3125 mL	0.6251 mL	3.1255 mL
50 mM	0.0250 mL	0.1250 mL	0.2500 mL	1.2502 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc