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GNE-493

Name: GNE-493
Brand: TargetMol
SKU: T7166
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7166Cas No. 1033735-94-2

GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR,respectively.

GNE-493

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Purity: 98%

Catalog No. T7166Cas No. 1033735-94-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	In Stock	In Stock
5 mg	$106	In Stock	In Stock
10 mg	$172	In Stock	In Stock
25 mg	$363	In Stock	In Stock
50 mg	$579	In Stock	In Stock
100 mg	$892	-	In Stock
1 mL x 10 mM (in DMSO)	$117	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR,respectively.
Targets&IC50	PI3Kγ:16 nM , mTOR:32 nM, PI3Kβ:12 nM , PI3Kα:3.4 nM , PI3Kδ:16 nM
In vivo	GNE-493 was tested in a human MCF7.1 breast cancer xenograft model with a PI3Kα activating mutation. Mice with xenografts received a daily oral dose of 10 mg/kg of GNE-493 for 21 continuous days. Comparable to results in the PC3 prostate cancer model, this treatment led to a 73% inhibition of tumor growth by day 21 compared to control. With similar drug exposure levels, GNE-493 demonstrated equivalent suppression of the PI3K pathway and, thus, comparable efficacy against MCF7.1 breast tumors.

Chemical Properties

Molecular Weight	372.44
Formula	C₁₇H₂₀N₆O₂S
Cas No.	1033735-94-2
Smiles	CC(C)(O)c1cc2nc(nc(N3CCOCC3)c2s1)-c1cnc(N)nc1
Relative Density.	1.408 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (120.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6850 mL	13.4250 mL	26.8500 mL	134.2498 mL
5 mM	0.5370 mL	2.6850 mL	5.3700 mL	26.8500 mL
10 mM	0.2685 mL	1.3425 mL	2.6850 mL	13.4250 mL
20 mM	0.1342 mL	0.6712 mL	1.3425 mL	6.7125 mL
50 mM	0.0537 mL	0.2685 mL	0.5370 mL	2.6850 mL
100 mM	0.0268 mL	0.1342 mL	0.2685 mL	1.3425 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc