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RAS activator compound 1

Name: RAS activator compound 1
Brand: TargetMol
SKU: T212717
Price: 113 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T212717 Copy Product Info

Purity: 99.22%

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RAS activator compound 1 is an effective small GTPase modulator and Ras-GTP signaling pathway activator. It sustainably enhances kinase cascade signaling by directly binding and stabilizing the active conformation of Ras with its effectors, commonly used to investigate Ras-driven hyperproliferation and oncogenesis.

Cas No. 1579978-17-8

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Pack Size	Price	USA Stock	Global Stock
1 mg	$113	-	In Stock
5 mg	$278	-	In Stock
10 mg	$455	-	In Stock
25 mg	$793	-	In Stock
50 mg	$1,090	-	In Stock
100 mg	$1,480	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.22%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	RAS activator compound 1 is an effective small GTPase modulator and Ras-GTP signaling pathway activator. It sustainably enhances kinase cascade signaling by directly binding and stabilizing the active conformation of Ras with its effectors, commonly used to investigate Ras-driven hyperproliferation and oncogenesis.
In vitro	RAS activator compound 1 increases RAS-GTP accumulation in HeLa cells by specifically targeting the allosteric site of SOS1 [1].

Chemical Properties

Molecular Weight	449.98
Formula	C₂₅H₂₈ClN₅O
Cas No.	1579978-17-8
Smiles	C(C=1C=2C(NC1)=CC=C(Cl)C2)N3CCC(NC([C@H](CC=4C=5C(NC4)=CC=CC5)N)=O)CC3
Relative Density.	no data available

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (177.79 mM), Sonication is recommended

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2223 mL	11.1116 mL	22.2232 mL	111.1160 mL
5 mM	0.4445 mL	2.2223 mL	4.4446 mL	22.2232 mL
10 mM	0.2222 mL	1.1112 mL	2.2223 mL	11.1116 mL
20 mM	0.1111 mL	0.5556 mL	1.1112 mL	5.5558 mL
50 mM	0.0444 mL	0.2222 mL	0.4445 mL	2.2223 mL
100 mM	0.0222 mL	0.1111 mL	0.2222 mL	1.1112 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RASactivatorcompound1

Related Tags: RAS activator compound 1 chemical structure | RAS activator compound 1 in vitro | RAS activator compound 1 formula | RAS activator compound 1 molecular weight