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DMCM hydrochloride

Name: DMCM hydrochloride
Brand: TargetMol
SKU: T11061
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11061Cas No. 1215833-62-7

DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 nM, 13 nM, 7.5 nM, 2.2 nM, respectively.

DMCM hydrochloride

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Purity: 99.56%

Catalog No. T11061Cas No. 1215833-62-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
2 mg	$45	In Stock	In Stock
5 mg	$77	In Stock	In Stock
10 mg	$113	-	In Stock
25 mg	$263	-	In Stock
50 mg	$488	-	In Stock
100 mg	$689	-	In Stock
1 mL x 10 mM (in DMSO)	$85	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.56%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 nM, 13 nM, 7.5 nM, 2.2 nM, respectively.
Targets&IC50	GABAA α3 receptor:7.5 nM (ki), GABAA α1 receptor:ki:10 nM , GABAA α5 receptor:2.2 nM (ki), GABAA α2 receptor:13 nM (ki)
In vivo	DMCM exhibits potent convulsant, proconvulsant, and anxiogenic properties in vivo. At doses of 20-60 mg/kg (i.p.), DMCM induces modest anxiolytic-like effects in γ2I77 mice[2].

Chemical Properties

Molecular Weight	350.8
Formula	C₁₇H₁₉ClN₂O₄
Cas No.	1215833-62-7
Smiles	Cl.CCc1c(ncc2[nH]c3cc(OC)c(OC)cc3c12)C(=O)OC
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 22.5 mg/mL (64.14 mM), Sonication is recommended.

DMSO: 9 mg/mL (25.66 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.8506 mL	14.2531 mL	28.5063 mL	142.5314 mL
5 mM	0.5701 mL	2.8506 mL	5.7013 mL	28.5063 mL
10 mM	0.2851 mL	1.4253 mL	2.8506 mL	14.2531 mL
20 mM	0.1425 mL	0.7127 mL	1.4253 mL	7.1266 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0570 mL	0.2851 mL	0.5701 mL	2.8506 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc