CD98 Protein, Human, Recombinant (mFc)

Name: CD98 Protein, Human, Recombinant (mFc)
Brand: TargetMol
SKU: TMPJ-00352
Rating: 4.5 (1 reviews)

(Synonyms: Solute carrier family 3 member 2, SLC3A2, MDU1, Lymphocyte activation antigen 4F2 large subunit, CD98, 4F2hc, 4F2 cell-surface antigen heavy chain) Copy Product Info

Synonyms: Solute carrier family 3 member 2, SLC3A2, MDU1, Lymphocyte activation antigen 4F2 large subunit, CD98, 4F2hc, 4F2 cell-surface antigen heavy chain

Catalog No. TMPJ-00352 Copy Product Info

CD98 is a multifunctional glycoprotein that is involved in various biological processes such as amino acid transport, cell adhesion, diffusion, adhesion, and proliferation. CD98 can interact with CD147 to induce integrin 1 function to promote cyclosporine B-induced cell adhesion and p44/p42 MAPK activation following PI3K activation. CD98 heavy chain has been studied to be a key player in tumorigenesis due to its role in activating integrin signaling to promote tumor progression via angiogenesis, invasiveness, and proliferation in addition to promoting malignant transformation of cells. Fibrotic progression in the liver could be linked to the activation of integrin αvβ1 via CD98. CD98's role in T cell activation in which the TGF activation could also play a profibrotic role.

Pack Size	Price	USA Stock	Global Stock
10 µg	$64	7-10 days	7-10 days
20 µg	$98	7-10 days	7-10 days
50 µg	$200	7-10 days	7-10 days
100 µg	$368	7-10 days	7-10 days
200 µg	$685	7-10 days	7-10 days
500 µg	$1,570	7-10 days	7-10 days
1 mg	$2,370	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	1. Loaded Anti-Human CD98 mAb-Fc on AHC Biosensor, can bind Human CD98-mFc with an affinity constant of <10^-3 nM as determined in BLI assay. (Regularly tested) 2. Immobilized Human CD98-mFc at 2μg/ml (100 μl/well) can bind Anti-Human CD98 mAb . The ED50 of Anti-Human CD98 mAb is 1.34 ng/ml. (Regularly tested)
Description	CD98 is a multifunctional glycoprotein that is involved in various biological processes such as amino acid transport, cell adhesion, diffusion, adhesion, and proliferation. CD98 can interact with CD147 to induce integrin 1 function to promote cyclosporine B-induced cell adhesion and p44/p42 MAPK activation following PI3K activation. CD98 heavy chain has been studied to be a key player in tumorigenesis due to its role in activating integrin signaling to promote tumor progression via angiogenesis, invasiveness, and proliferation in addition to promoting malignant transformation of cells. Fibrotic progression in the liver could be linked to the activation of integrin αvβ1 via CD98. CD98's role in T cell activation in which the TGF activation could also play a profibrotic role.
Species	Human
Expression System	HEK293 Cells
Tag	N-mFc
Accession Number	P08195
Amino Acid	Arg206-Ala630
Construction	Arg206-Ala630
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH7.4.
Synonyms	Solute carrier family 3 member 2, SLC3A2, MDU1, Lymphocyte activation antigen 4F2 large subunit, CD98, 4F2hc, 4F2 cell-surface antigen heavy chain
Research Background	CD98 is a multifunctional glycoprotein that is involved in various biological processes such as amino acid transport, cell adhesion, diffusion, adhesion, and proliferation. CD98 can interact with CD147 to induce integrin 1 function to promote cyclosporine B-induced cell adhesion and p44/p42 MAPK activation following PI3K activation. CD98 heavy chain has been studied to be a key player in tumorigenesis due to its role in activating integrin signaling to promote tumor progression via angiogenesis, invasiveness, and proliferation in addition to promoting malignant transformation of cells. Fibrotic progression in the liver could be linked to the activation of integrin αvβ1 via CD98. CD98’s role in T cell activation in which the TGF activation could also play a profibrotic role.

Chemical Properties

Molecular Weight

70-100 KDa (reducing condition)

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.