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Epiandrosterone

Name: Epiandrosterone
Brand: TargetMol
SKU: T2195
Rating: 4.5 (1 reviews)

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Catalog No. T2195Cas No. 481-29-8

Alias trans-Androsterone, iso-Androsterone, EpiA, 3β-Androsterone

Epiandrosterone (EpiA) is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property.

Epiandrosterone

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Purity: 99.88%

Catalog No. T2195Alias trans-Androsterone, iso-Androsterone, EpiA, 3β-AndrosteroneCas No. 481-29-8

Epiandrosterone (EpiA) is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property.

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Batch Information

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Purity:99.88%

Appearance:solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Epiandrosterone (EpiA) is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property.
In vivo	Epiandrosterone is only a weak androgen, but is widely recognized to inhibit the pentose phosphate pathway and reduce intracellular levels of reduced coenzyme II.Epiandrosterone is formed in peripheral tissues, released into the circulation, and ultimately excreted in the urine.Epiandrosterone reduces NO-induced relaxation of the pulmonary arteries, and, while Epiandrosterone acts on isolated lungs to inhibit angiotensin II- and hypoxia-induced vasoconstriction and to relax isolated pulmonary arteries preconstricted by KCl.
Synonyms	trans-Androsterone, iso-Androsterone, EpiA, 3β-Androsterone

Chemical Properties

Molecular Weight	290.44
Formula	C₁₉H₃₀O₂
Cas No.	481-29-8
Smiles	C[C@]12CC[C@@H](C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CCC2=O)C)O
Relative Density.	1.085 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: <1 mg/mL

DMSO: 28 mg/mL (96.41 mM), Sonication is recommended.

Ethanol: 54 mg/mL (185.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (6.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.4431 mL	17.2153 mL	34.4305 mL	172.1526 mL
5 mM	0.6886 mL	3.4431 mL	6.8861 mL	34.4305 mL
10 mM	0.3443 mL	1.7215 mL	3.4431 mL	17.2153 mL
20 mM	0.1722 mL	0.8608 mL	1.7215 mL	8.6076 mL
50 mM	0.0689 mL	0.3443 mL	0.6886 mL	3.4431 mL

Ethanol

	1mg	5mg	10mg	50mg
100 mM	0.0344 mL	0.1722 mL	0.3443 mL	1.7215 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc