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Anti-B7-1 Antibody-APC (5N350)
🥰Excellent
Catalog No. TMAY-03297A
Anti-B7-1 Antibody-APC (5N350) is a APC-conjugated Rabbit antibody targeting B7-1. Anti-B7-1 Antibody-APC (5N350) can be used in FCM.
Anti-B7-1 Antibody-APC (5N350)
Anti-B7-1 Antibody-APC (5N350)
🥰Excellent
Catalog No. TMAY-03297A
Anti-B7-1 Antibody-APC (5N350) is a APC-conjugated Rabbit antibody targeting B7-1. Anti-B7-1 Antibody-APC (5N350) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-B7-1 Antibody-APC (5N350) is a APC-conjugated Rabbit antibody targeting B7-1. Anti-B7-1 Antibody-APC (5N350) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 5N350 |
| Reactivity | Mouse |
| Verified Activity | Flow cytometric analysis of Mouse CD80 expression on LPS-stimulated BABL/c splenocytes. Cells were stained with APC-conjugated anti-Mouse CD80. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD80/B7-1 (rM CD80/B7-1; TMPY-02307; Q00609-1; Met1-Lys245) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| Conjucates | APC |
| Others Formats | Unconjugated/PE |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Mouse CD80/B7-1 Protein (TMPY-02307) |
| Antigen Species | Mouse |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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