IL-6R alpha/CD126 Protein, Human, Recombinant (Insect, His)

Name: IL-6R alpha/CD126 Protein, Human, Recombinant (Insect, His)
Brand: TargetMol
SKU: TMPS-00128
Rating: 4.5 (1 reviews)

(Synonyms: sIL6RA, Membrane glycoprotein 80, Interleukin-6 receptor subunit alpha, IL-6RA, IL-6R subunit alpha, IL-6R 1, gp80, CD_antigen: CD126) Copy Product Info

Synonyms: sIL6RA, Membrane glycoprotein 80, Interleukin-6 receptor subunit alpha, IL-6RA, IL-6R subunit alpha, IL-6R 1, gp80, CD_antigen: CD126

Catalog No. TMPS-00128 Copy Product Info

IL-6R alpha/CD126 Protein, Human, Recombinant (Insect, His) is expressed in Baculovirus Insect Cells. The accession number is P08887-1.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$71	7-10 days	7-10 days
10 µg	$113	7-10 days	7-10 days
20 µg	$197	7-10 days	7-10 days
50 µg	$423	7-10 days	7-10 days
100 µg	$682	7-10 days	7-10 days
200 µg	$1,080	7-10 days	7-10 days
500 µg	$1,980	7-10 days	7-10 days
1 mg	$3,390	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	ED 50 < 50.0 ng/ml, measured by the cytotoxicity assay using M1 cells in presence of 10.0 ng/ml of human IL-6, corresponding to a specific activity of > 2.0 × 10 4 units/mg.
Description	IL-6R alpha/CD126 Protein, Human, Recombinant (Insect, His) is expressed in Baculovirus Insect Cells. The accession number is P08887-1.
Species	Human
Expression System	Baculovirus Insect Cells
Tag	His
Accession Number	P08887-1
Construction	Leu20-Asp358
Protein Purity	> 95% as determined by SDS-PAGE; > 95% as determined by HPLC
Endotoxin	< 0.2 EU/μg of protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	sIL6RA, Membrane glycoprotein 80, Interleukin-6 receptor subunit alpha, IL-6RA, IL-6R subunit alpha, IL-6R 1, gp80, CD_antigen: CD126
Research Background	Interleukin-6 Receptor (IL-6R) is a single trans-membrane protein that is the receptor for Interleukin-6 (IL-6). IL-6R forms a hexameric complex upon binding 2 molecules of IL-6 and two molecules of glycoprotein 130 (gp130) which activates intracellular JAK/STAT pathways. Although the normal form of IL-6R is the membrane-bound 80 kDa subunit, a soluble form of IL-6R (sIL-6R) can be generated physiologically by limited proteolysis or alternative splicing. sIL-6R binds to both IL-6 and gp130 generating intracellular signaling. In the immune system, sIL-6R is produced by both naïve and memory CD4 T-cells and strongly augments IL-6 ligand’s induction of Th-17 cells.

Chemical Properties

Molecular Weight

~50 kDa (Reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

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Related Tags: IL-6R alpha/CD126 Protein, Human, Recombinant (Insect, His) chemical structure | IL-6R alpha/CD126 Protein, Human, Recombinant (Insect, His) molecular weight