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Anti-CD71/TfR1 Antibody (Jr-141 Naked Antibody)
(Synonyms: JR-141 antibody (uncoupled from iduronate 2-sulfatase), Anti-human CD71/TfR1 Antibody) Copy Product Info
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Synonyms: JR-141 antibody (uncoupled from iduronate 2-sulfatase), Anti-human CD71/TfR1 Antibody
Catalog No. T9901A-762 Copy Product Info
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Anti-CD71/TfR1 Antibody (Jr-141 Naked Antibody) is a sophisticated humanized monoclonal antibody target the human transferrin receptor 1 (TfR1/CD71) with a measured dissociation constant (Kd) of 1.12 nM, functioning as the foundational component of the J-Brain Cargo technology for research involving receptor-mediated transcytosis across the blood-brain barrier.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | 8-10 weeks | 8-10 weeks | |
| 5 mg | Inquiry | 8-10 weeks | 8-10 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Antibody Information
Storage & Solubility Information
| Description | Anti-CD71/TfR1 Antibody (Jr-141 Naked Antibody) is a sophisticated humanized monoclonal antibody target the human transferrin receptor 1 (TfR1/CD71) with a measured dissociation constant (Kd) of 1.12 nM, functioning as the foundational component of the J-Brain Cargo technology for research involving receptor-mediated transcytosis across the blood-brain barrier. |
| Targets & IC50 | CD71:26.4 ng/mL (EC50), Transferrin Receptor:1.12 nM (Kd) |
| In vitro | In SPR binding kinetics assays, Anti-CD71/TfR1 Antibody (Jr-141 Naked Antibody) bound to human TfR1 with a Kd of 1.12 nM and demonstrated a binding EC50 of 26.4 ng/mL [1]. |
| In vivo | In cynomolgus monkey models, systemic administration of Anti-CD71/TfR1 Antibody (Jr-141 Naked Antibody) at 2 mg/kg resulted in significant brain parenchyma accumulation [1]. |
| Synonyms | JR-141 antibody (uncoupled from iduronate 2-sulfatase), Anti-human CD71/TfR1 Antibody |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | CD71/TfR1 |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Anti-CD71/TfR1 Antibody (Jr-141 Naked Antibody) chemical structure | Anti-CD71/TfR1 Antibody (Jr-141 Naked Antibody) in vivo | Anti-CD71/TfR1 Antibody (Jr-141 Naked Antibody) in vitro
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