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VU0810464

🥰Excellent
Catalog No. T7899Cas No. 2126040-21-7

VU0810464 is a non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator.

VU0810464

VU0810464

🥰Excellent
Purity: 99.62%
Catalog No. T7899Cas No. 2126040-21-7
VU0810464 is a non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$39In StockIn Stock
5 mg$96In StockIn Stock
10 mg$153In StockIn Stock
25 mg$257In StockIn Stock
50 mg$343In StockIn Stock
100 mg$457In StockIn Stock
200 mg$622-In Stock
1 mL x 10 mM (in DMSO)$106In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.62%
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Product Introduction

Bioactivity
Description
VU0810464 is a non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator.
Targets&IC50
GIRK1/2:165 nM(EC50) , GIRK1/4:720 nM(EC50)
In vivo
Reduced stress‐induced hyperthermia (SIH), a physiological test of anxiolytic efficacy in wild mice, but had no impact in and Kcnj3 (Girk1) ?/? mice.
Animal Research
Animal Model:Male C57BL/6J mice, Kcnj3?/? siblings female and male C57BL/6J mice. Dosage:10 mg/kg; 30mg/kg. Administration:Intraperitoneal injection
Chemical Properties
Molecular Weight349.83
FormulaC18H21ClFN3O
Cas No.2126040-21-7
SmilesCc1cc(NC(=O)Cc2ccc(F)c(Cl)c2)n(n1)C1CCCCC1
Relative Density.1.31 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 250 mg/mL (714.63 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (14.29 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8585 mL14.2927 mL28.5853 mL142.9266 mL
5 mM0.5717 mL2.8585 mL5.7171 mL28.5853 mL
10 mM0.2859 mL1.4293 mL2.8585 mL14.2927 mL
20 mM0.1429 mL0.7146 mL1.4293 mL7.1463 mL
50 mM0.0572 mL0.2859 mL0.5717 mL2.8585 mL
100 mM0.0286 mL0.1429 mL0.2859 mL1.4293 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

VU-0810464VU0810464VU 0810464SANPotassiumChannelPotassium Channelneuronal GIRKKcsAInhibitorinhibitHPCGIRKcells
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