Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HB007 is a potent degrader of small ubiquitin-related modifier 1 (SUMO1). It mediates the ubiquitination and subsequent degradation of SUMO1, leading to a decrease in tumor growth in vivo. HB007 is a valuable tool for investigating brain, breast, colon, and lung cancers[1][2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 854.00 | |
50 mg | 6-8 weeks | $ 1,110.00 | |
100 mg | 6-8 weeks | $ 1,610.00 |
Description | HB007 is a potent degrader of small ubiquitin-related modifier 1 (SUMO1). It mediates the ubiquitination and subsequent degradation of SUMO1, leading to a decrease in tumor growth in vivo. HB007 is a valuable tool for investigating brain, breast, colon, and lung cancers[1][2]. |
In vitro | HB007 (compound 24), at concentrations ranging from 0.1 to 100 μM, effectively inhibits the growth of LN229 cells in a dose-dependent manner [t1]. Additionally, at concentrations between 10 and 25 μM, HB007 selectively decreases both the conjugation and overall protein levels of SUMO1, without affecting the levels of SUMO2/3 or ubiquitin (UB) in LN229 cells [t1]. |
In vivo | HB007 (compound 24) (25-50 mg/kg; intraperitoneally administered for 15 days) significantly reduced the growth of colon and lung tumors without affecting the mice's body weight[1]. |
Molecular Weight | 328.78 |
Formula | C15H9ClN4OS |
CAS No. | 2387821-46-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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HB007 2387821-46-5 HB-007 HB 007 inhibitor inhibit