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HB007
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Catalog No. T37646Cas No. 2387821-46-5
Alias HB-007, HB 007
HB007 is an effective SUMO1 degradation agent that inhibits tumor growth by inducing SUMO1 ubiquitination and degradation, increasing endoplasmic reticulum (ER) stress and ROS production, suitable for cancer research.
HB007
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Purity: 99.76%
Catalog No. T37646Alias HB-007, HB 007Cas No. 2387821-46-5
HB007 is an effective SUMO1 degradation agent that inhibits tumor growth by inducing SUMO1 ubiquitination and degradation, increasing endoplasmic reticulum (ER) stress and ROS production, suitable for cancer research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $100 | - | In Stock | |
| 5 mg | $247 | - | In Stock | |
| 10 mg | $378 | - | In Stock | |
| 25 mg | $745 | - | In Stock | |
| 50 mg | $1,090 | - | In Stock | |
| 100 mg | $1,590 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $272 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.76%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | HB007 is an effective SUMO1 degradation agent that inhibits tumor growth by inducing SUMO1 ubiquitination and degradation, increasing endoplasmic reticulum (ER) stress and ROS production, suitable for cancer research. |
| In vitro | HB007 (compound 24) exhibited concentration-dependent inhibition of LN229 cell proliferation within the concentration range of 0.1-100 μM [1]. HB007 (10-25 μM) reduced the binding efficiency of SUMO1 and its total protein expression levels in LN229 cells, but showed no significant effect on the expression of SUMO2/3 or ubiquitin (UB) [1]. |
| In vivo | HB007 (25-50 mg/kg) was administered to mice via intraperitoneal injection for 15 consecutive days, which significantly inhibited tumor growth in carcinoma of the colon and lung cancer without an obvious impact on the body weight of mice [1]. |
| Synonyms | HB-007, HB 007 |
| Molecular Weight | 328.78 |
| Formula | C15H9ClN4OS |
| Cas No. | 2387821-46-5 |
| Smiles | N#CC=1C=CC=2N=C(SC2C1)NC(=O)NC=3C=CC=C(Cl)C3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 24 mg/mL (73 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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