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HB007
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Catalog No. T37646Cas No. 2387821-46-5
Alias HB-007, HB 007
HB007 is an effective SUMO1 degradation agent that inhibits tumor growth by inducing SUMO1 ubiquitination and degradation, increasing endoplasmic reticulum (ER) stress and ROS production, suitable for cancer research.
HB007
😃Good
Catalog No. T37646Alias HB-007, HB 007Cas No. 2387821-46-5
HB007 is an effective SUMO1 degradation agent that inhibits tumor growth by inducing SUMO1 ubiquitination and degradation, increasing endoplasmic reticulum (ER) stress and ROS production, suitable for cancer research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $854 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $1,110 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $1,610 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | HB007 is an effective SUMO1 degradation agent that inhibits tumor growth by inducing SUMO1 ubiquitination and degradation, increasing endoplasmic reticulum (ER) stress and ROS production, suitable for cancer research. |
| In vitro | HB007 (compound 24) exhibited concentration-dependent inhibition of LN229 cell proliferation within the concentration range of 0.1-100 μM [1]. HB007 (10-25 μM) reduced the binding efficiency of SUMO1 and its total protein expression levels in LN229 cells, but showed no significant effect on the expression of SUMO2/3 or ubiquitin (UB) [1]. |
| In vivo | HB007 (25-50 mg/kg) was administered to mice via intraperitoneal injection for 15 consecutive days, which significantly inhibited tumor growth in carcinoma of the colon and lung cancer without an obvious impact on the body weight of mice [1]. |
| Synonyms | HB-007, HB 007 |
| Molecular Weight | 328.78 |
| Formula | C15H9ClN4OS |
| Cas No. | 2387821-46-5 |
| Smiles | N#CC=1C=CC=2N=C(SC2C1)NC(=O)NC=3C=CC=C(Cl)C3 |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 24 mg/mL (73 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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