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EGFR-IN-12
🥰Excellent
Catalog No. T5168Cas No. 879127-07-8
Alias EGFR Inhibitor
EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.
EGFR-IN-12
🥰Excellent
Purity: 99.76%
Catalog No. T5168Alias EGFR InhibitorCas No. 879127-07-8
EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $75 | In Stock | |
| 5 mg | $162 | In Stock | |
| 10 mg | $272 | In Stock | |
| 25 mg | $547 | In Stock | |
| 50 mg | $779 | In Stock | |
| 100 mg | $1,060 | In Stock | |
| 500 mg | $2,120 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $177 | In Stock |
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Purity:99.76%
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Product Introduction
Bioactivity
Chemical Properties
| Description | EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells. |
| Targets&IC50 | HER4:7640 nM, EGFR (L858R):63 nM (cell free), EGFR (L861Q):4 nM (cell free), EGFR:21 nM (cell free) |
| In vitro | EGFR Inhibitor possesses an enzymatic IC50= 21 nM against EGFR kinase in vitro and blocks receptor autophosphorylation in cells. EGFR Inhibitor also potently inhibits two EGFR mutants associated with clinical response to gefitinib: L858R (IC50: 63 nM) and L861Q (IC50: 4 nM), but displays much weaker activity against Her 4 (IC50: 7640 nM). |
| Synonyms | EGFR Inhibitor |
| Molecular Weight | 413.4 |
| Formula | C21H18F3N5O |
| Cas No. | 879127-07-8 |
| Smiles | FC(F)(F)c1cccc(Nc2cc(Nc3cccc(NC(=O)C4CC4)c3)ncn2)c1 |
| Relative Density. | 1.456 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 10 mg/mL (24.19 mM), Sonication is recommended. DMSO: 50 mg/mL (120.95 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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