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Lycorine
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Catalog No. T3324Cas No. 476-28-8
Alias Narcissine, Licorine, Galanthidine, Belamarine, Amarylline
Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
Lycorine
Copy Product Info🥰Excellent
Purity: 99.95%
Catalog No. T3324Alias Narcissine, Licorine, Galanthidine, Belamarine, AmaryllineCas No. 476-28-8
Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $30 | In Stock | In Stock | |
| 25 mg | $48 | In Stock | In Stock | |
| 50 mg | $68 | In Stock | In Stock | |
| 100 mg | $109 | In Stock | In Stock | |
| 500 mg | $263 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.95%
Color:White to Yellow
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Product Introduction
Lycorine AI Summary
Lycorine demonstrates a wide range of biological activities:
1. **Acetylcholinesterase Inhibition**: It acts as an inhibitor of acetylcholinesterase (AChE) with an IC50 value of 155,000 nM, showcasing a moderate potential in inhibiting this enzyme.
2. **Anti-inflammatory effects**: The compound inhibits LPS-induced NO production in mouse macrophages with an IC50 of 2,500.0 nM after 20 hours and shows varying inhibition percentages from 0% to 91% at different concentrations (1-100 µM).
3. **Antitumor Activity**: In vivo antitumor efficacy is observed in mouse P388 cells at 75 mg/kg, with a T/C value of 135%.
4. **Ascorbic Acid Biosynthesis**: Inhibits ascorbic acid biosynthesis in potato tubers by 80.0% at a concentration of 20 µM.
5. **Antiviral Properties**: Exhibits antiviral activity against several viruses, including Herpes simplex, Semliki forest, Poliovirus, Measles, Japanese encephalitis, Yellow fever, Dengue type 4, Punta Toro, Rift Valley fever, Human enterovirus 71, SARS-CoV, SARS-CoV-2, and Zika, with varying efficacy and therapeutic indices.
6. **Antimicrobial Activity**: Shows antibacterial activity against Escherichia coli and Staphylococcus aureus but not against Corynebacterium fascians.
7. **Antiplasmodial Activity**: Inhibits Plasmodium falciparum strains D6 and W2 with IC50 values of 320.0 and 300.0 µg/mL, respectively, and exhibits activity against Trichomonas vaginalis and Entamoeba histolytica.
8. **Cytotoxicity Against Various Cell Lines**: Demonstrates cytotoxic effects against a multitude of human and mouse cell lines (LUC1, SK-MEL-2, Col1, KB, KBV1, A431, LNCAP, ZR-75-1, U373, BCA1, HT1080, etc.), with IC50 values ranging from 0.3 to 1.6 µg/mL for different cell types.
9. **Epigenetic Modulation**: Exhibits potency in enhancing SMN2 splice variant expression, regulating epigenetic control, and inhibiting histone lysine methyltransferase.
10. **Antimalarial Activity**: Shows activity against Plasmodium falciparum with IC50 values of 0.62 µg/mL and 130.0 nM for different assays.
11. **G Protein Signaling Regulation**: Inhibits regulators of G protein signaling (RGS4) with an IC50 of 4,744.4 nM.
12. **Inhibition of GLI1-mediated Transcription**: The compound inhibits GLI1-mediated transcriptional activity in human HaCaT cells with an IC50 of 19,000 nM.
Overall, Lycorine exhibits significant multifunctional bioactivity, including anti-inflammatory, antitumor, antiviral, antimicrobial, antiplasmodial, and cytotoxic effects against various cell lines, making it a promising candidate for further research and development in multiple therapeutic areas..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive. |
| Targets&IC50 | SCAP:15.24 nM (Kd) |
| Synonyms | Narcissine, Licorine, Galanthidine, Belamarine, Amarylline |
| Molecular Weight | 287.31 |
| Formula | C16H17NO4 |
| Cas No. | 476-28-8 |
| Smiles | [H][C@@]12N3CCC1=C[C@H](O)[C@@H](O)[C@@]2([H])c1cc2OCOc2cc1C3 |
| Relative Density. | 1.53g/cm3 |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5.63 mg/mL (19.6 mM), Sonication is recommended.  | ||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.48 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
VirusProteaseVirus ProteasetumorSREBF chaperoneSCAPprostatePCametabolicLycorineInhibitorinhibitHL-7702HFDFattyAcidSynthasefatty liverFatty Acid Synthase (FASN)Fatty Acid SynthaseER stressdyslipidemiacancerBacterialApoptosisantiviralanti-prostateantimalarialantiinflammationAmaryllidaceaeAChRABCG8ABCG5
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