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KH-259
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Catalog No. T61073
KH-259 (compound 1) is a highly potent, selective, and CNS-penetrant HDAC6 inhibitor, with an IC50 of 0.26 μM, exerting antidepressant effects in mice by inhibiting HDAC6 within the brain and holding promise as a valuable tool for neurodegenerative diseases research [1].
KH-259
KH-259
😃Good
Catalog No. T61073
KH-259 (compound 1) is a highly potent, selective, and CNS-penetrant HDAC6 inhibitor, with an IC50 of 0.26 μM, exerting antidepressant effects in mice by inhibiting HDAC6 within the brain and holding promise as a valuable tool for neurodegenerative diseases research [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 10-14 weeks | 10-14 weeks | |
| 50 mg | $1,980 | 10-14 weeks | 10-14 weeks | |
| 100 mg | $2,500 | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | KH-259 (compound 1) is a highly potent, selective, and CNS-penetrant HDAC6 inhibitor, with an IC50 of 0.26 μM, exerting antidepressant effects in mice by inhibiting HDAC6 within the brain and holding promise as a valuable tool for neurodegenerative diseases research [1]. |
| Targets&IC50 | HDAC4:12.3 ± 0.4 μM, HDAC1:6.7 ± 0.14 μM, HDAC6:0.26 ± 0.2 μM |
| In vitro | KH-259 (compound 1) shows satisfactory metabolic stability in liver microsomes of both mice and humans [1]. |
| In vivo | Administration of KH-259 (compound 1) (10 mg/kg, IP, once) significantly raises acetylated α-tubulin levels in mice brains without affecting acetylated histone H3K9 levels, suggesting its antidepressant effects are mediated through inhibiting HDAC6 in the brain [1]. |
| Molecular Weight | 339.43 |
| Formula | C20H25N3O2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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