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2-Hydroxycinnamic acid

Name: 2-Hydroxycinnamic acid
Brand: TargetMol
SKU: T7991
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7991Cas No. 614-60-8

2-Hydroxycinnamic acid is a natural product isolated from Angraecum fragrans, has photooxidant activity.

2-Hydroxycinnamic acid

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Purity: 99.89%

Catalog No. T7991Cas No. 614-60-8

2-Hydroxycinnamic acid is a natural product isolated from Angraecum fragrans, has photooxidant activity.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$35	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

2-Hydroxycinnamic acid AI Summary

2-Hydroxycinnamic acid exhibits a diverse range of bioactivities, notably inhibiting Cyclin D1-cyclin-dependent kinase 4, albeit with less than 10% inhibition. It induces NAD(P)H quinone reductase activity in Hepa 1c1c7 cells with an effective concentration of 19.0 µM and shows 11.0% inhibition of beta-hexosaminidase release from RBL-2H3 cells at 100 µM. The compound inhibits alpha-glucosidase activity with an IC50 greater than 5000 µM and has a weak effect on nitric oxide production in activated macrophages, exhibiting 7.0% inhibition at 100 µM. In terms of antioxidant properties, 2-Hydroxycinnamic acid demonstrates DPPH radical scavenging activity ranging from 2.1% to 3.6%. It also shows bioactivity as an inhibitor of mushroom tyrosinase (IC50 = 670 µM) and multiple human carbonic anhydrase isoforms, with Ki values for CA1 and CA2 being 3.1 µM and 9.2 µM, respectively. Its effects on other isoforms are weak or negligible. Additionally, the compound inhibits the NF-KB p50 subunit/DNA interaction with an IC50 of 50 µM and displays antihemorrhagic properties against snake venom-induced hemorrhage with an IC50 of 190 nM. It exhibits moderate to potent inhibition of xanthine oxidase (IC50 = 32.2 µg/mL) and TP_TRANSPORTER activity. 2-Hydroxycinnamic acid also possesses antibacterial activity against several strains, including Ralstonia solanacearum (inhibition zone of 16 mm at 5 µmol/disk) and Mycobacterium species, with varying MIC values. Its antiplatelet activity inhibits ADP-induced aggregation with an IC50 of 115.8 µM, and it shows antineuroinflammatory effects with an IC50 greater than 100 µM. Further, the compound has shown efficacy in inhibiting protozoan diseases, including Leishmania and Trypanosoma species, and has a peak electrochemical potential of 750 mV. It exhibits a broad spectrum of activities, including cytotoxic effects on mouse RAW264.7 cells, making it a compound of interest for multiple therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

2-Hydroxycinnamic acid is a natural product isolated from Angraecum fragrans, has photooxidant activity.

Chemical Properties

Molecular Weight	164.16
Formula	C₉H₈O₃
Cas No.	614-60-8
Smiles	OC(=O)\C=C\c1ccccc1O
Relative Density.	1.329g/cm3

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (1218.32 mM)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (30.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0916 mL	30.4581 mL	60.9162 mL	304.5809 mL
5 mM	1.2183 mL	6.0916 mL	12.1832 mL	60.9162 mL
10 mM	0.6092 mL	3.0458 mL	6.0916 mL	30.4581 mL
20 mM	0.3046 mL	1.5229 mL	3.0458 mL	15.2290 mL
50 mM	0.1218 mL	0.6092 mL	1.2183 mL	6.0916 mL
100 mM	0.0609 mL	0.3046 mL	0.6092 mL	3.0458 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc