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Anti-MFN1 Polyclonal Antibody

😃Good
Catalog No. TMAB-01131
Alias Transmembrane GTPase MFN1, Mitofusin-1, MFN 1, Fzo homolog

Anti-MFN1 Polyclonal Antibody is a Rabbit antibody targeting MFN1. Anti-MFN1 Polyclonal Antibody can be used in FCM.

Anti-MFN1 Polyclonal Antibody

Anti-MFN1 Polyclonal Antibody

😃Good
Catalog No. TMAB-01131Alias Transmembrane GTPase MFN1, Mitofusin-1, MFN 1, Fzo homolog
Anti-MFN1 Polyclonal Antibody is a Rabbit antibody targeting MFN1. Anti-MFN1 Polyclonal Antibody can be used in FCM.
Pack SizePriceAvailabilityQuantity
50 μL$2227-10 days
100 μL$3727-10 days
200 μL$5287-10 days
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Product Introduction

Bioactivity
Description
Anti-MFN1 Polyclonal Antibody is a Rabbit antibody targeting MFN1. Anti-MFN1 Polyclonal Antibody can be used in FCM.
AliasTransmembrane GTPase MFN1, Mitofusin-1, MFN 1, Fzo homolog
Ig Type
IgG
Reactivity
Rat (predicted:Human,Mouse,Horse,Rabbit)
Verified Activity
Blank control: RSC96 (blue), the cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with ice-cold 90% methanol for 30 min on ice.
Isotype Control Antibody: Rabbit Igg (orange);
Secondary Antibody: Goat anti-rabbit IgG-Pe (white blue),
Dilution: 1:200 in 1 X PBS containing 0.5% BSA;
Primary Antibody Dilution: 1 μg in 100 μL 1X PBS containing 0.5% BSA (green).
Application
FCM
Recommended Dose
FCM: 1μg/Test
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm and Mitochondrion outer membrane.
ConstructionHybridoma Polyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Research BackgroundMitofusin 1 (Mfn1) and mitofusin 2 (Mfn2) are homologs for the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins and are mediators of mitochondrial fusion. A GTPase domain is required for Mfn protein function but the molecular mechanisms of the GTPase-dependent reaction as well as the functional division of the two Mfn proteins are unknown. They are essential for embryonic development and may play a role in the pathobiology of obesity. Although the Mfn1 and Mfn2 genes are broadly expressed, they show different levels of expression in different tissues. Two Mfn1 transcripts are elevated in heart, while Mfn2 mRNA is abundantly expressed in heart and muscle tissue but present only at low levels in many other tissues. Mfn1 localizes to mitochondria and participates in at least two different high molecular weight protein complexes in a GTP-dependent manner. Purified recombinant Mfn1 exhibited approximately eightfold higher GTPase activity than Mfn2.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human Mfn 1
Antigen Species
Human
Gene ID
Uniprot ID
Biology Area
Mitochondrial markers,Mitophagy fission and fusion,Parkinson's disease,GTP,Mitochondria
Chemical Properties
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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