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Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | Inquiry | 7-10 days | |
500 mg | Inquiry | 7-10 days |
Description | Hydroxy-PEG4-CH2-Boc is a PEG-based linker used in PROTACs, facilitating the conjugation of two critical ligands necessary for PROTAC molecule formation. This linker enables selective protein degradation by exploiting the ubiquitin-proteasome system within cells. |
In vitro | PROTACs feature two distinct ligands linked together: one ligand targets an E3 ubiquitin ligase, and the other binds to the target protein. They leverage the [intracellular ubiquitin-proteasome system] to selectively degrade target proteins. |
Molecular Weight | 308.37 |
Formula | C14H28O7 |
Cas No. | 169751-72-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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